Xifaxan and Requip drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Xifaxan (rifaximin) and Requip (ropinirole hydrochloride). Common drug interactions include blindness among females and decreased appetite among males.

The phase IV clinical study analyzes what interactions people have when they take Xifaxan and Requip. It is created by eHealthMe based on reports of 39 people who take the same drugs from the FDA, and is updated regularly.

What is Xifaxan?

Xifaxan has active ingredients of rifaximin. It is often used in irritable bowel syndrome. eHealthMe is studying from 16,609 Xifaxan users. Check the latest studies of Xifaxan.

What is Requip?

Requip has active ingredients of ropinirole hydrochloride. It is often used in restless leg syndrome. eHealthMe is studying from 22,950 Requip users. Check the latest studies of Requip.

On Jul, 09, 2026

39 people who take Xifaxan and Requip together, and have interactions are studied.

What are the common drug interactions of Xifaxan and Requip, by gender? *:

female:

Blindness
Blood glucose increased
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Dehydration (dryness resulting from the removal of water)
Diabetes mellitus inadequate control
Dizziness
Hepatic cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue)
Hepatomegaly (abnormal enlargement of the liver)
Hyperkalaemia (damage to or disease of the kidney)
Hypersomnia (excessive daytime sleepiness (eds))

male:

Decreased appetite
Bone pain
Hospitalisation
Osteoporosis (bones weak and more likely to break)
Abdominal pain
Blood creatinine increased
Blood glucose increased
Blood pressure increased
Blood urine present
Diarrhoea

What are the common drug interactions of Xifaxan and Requip, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Dehydration (dryness resulting from the removal of water)
Diabetes mellitus inadequate control
Diarrhoea
Dizziness
Hepatomegaly (abnormal enlargement of the liver)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Iron deficiency anaemia
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Nephrolithiasis (calculi in the kidneys)

30-39:

n/a

40-49:

Nausea (feeling of having an urge to vomit)
Dyspnoea (difficult or laboured respiration)
Blood glucose fluctuation
Diarrhoea
Loss of consciousness
Malabsorption (a state arising from abnormality in absorption of food nutrients across the gastrointestinal (gi) tract)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Retching (strong involuntary effort to vomit)
Systemic lupus erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue)
Vomiting

50-59:

Bone pain
Drug ineffective
Fanconi syndrome acquired (self developed genetic disease of kidney damage due to defective transport system)
Abdominal pain
Blood creatinine increased
Blood glucose increased
Blood pressure increased
Blood urine present
Decreased appetite
Diarrhoea

60+:

Abasia (inability to walk)
Confusional state
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Decreased appetite
Dementia (madness)
Drug ineffective
Hepatic failure (liver failure)
Hospitalisation
Osteoporosis (bones weak and more likely to break)
Peritonitis bacterial (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs by bacterial)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 14 people, 35.90%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 5 people, 12.82%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 10.26%
Hepatic Encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure): 3 people, 7.69%
Hepatic Cirrhosis (chronic liver disease characterized by replacement of liver tissue by fibrosis, scar tissue): 3 people, 7.69%
Pain: 2 people, 5.13%
Nausea And Vomiting: 2 people, 5.13%
Nausea (feeling of having an urge to vomit): 2 people, 5.13%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 5.13%
High Blood Pressure: 2 people, 5.13%

* Approximation only. Some reports may have incomplete information.

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