Xopenex and Excedrin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Xopenex (levalbuterol hydrochloride) and Excedrin (acetaminophen; aspirin; caffeine). Common drug interactions include injection site erythema among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Xopenex and Excedrin. It is created by eHealthMe based on reports of 79 people who take the same drugs from the FDA, and is updated regularly.

What is Xopenex?

Xopenex has active ingredients of levalbuterol hydrochloride. It is often used in asthma. eHealthMe is studying from 13,816 Xopenex users. Check the latest studies of Xopenex.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

On Jul, 11, 2026

79 people who take Xopenex and Excedrin together, and have interactions are studied.

What are the common drug interactions of Xopenex and Excedrin, by gender? *:

female:

Injection site erythema (redness at injection site)
Intraocular pressure increased
Loss of consciousness
Medical device complication
Muscle atrophy (a decrease in the mass of the muscle)
Oedema peripheral (superficial swelling)
Pain in extremity
Pancreatitis (inflammation of pancreas)
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Scar

male:

Pneumonia
Aortic arteriosclerosis (hardening of the aortic arteries)
Abdominal pain upper
Dyspnoea (difficult or laboured respiration)
Ear congestion
Feeding disorder (when children refuse to eat certain food groups)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hot flush (sudden feelings of heat)
Hypoaesthesia (reduced sense of touch or sensation)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)

What are the common drug interactions of Xopenex and Excedrin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Dyspnoea (difficult or laboured respiration)
Muscle rigidity (muscle stiffness)
Petechiae (a small red or purple spot caused by bleeding into the skin)
Pruritus (severe itching of the skin)
Skin haemorrhage (bleeding into skin)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Vision blurred

20-29:

Eye disorder
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Choking sensation (feeling of obstruction in respiratory system)
Dyspnoea (difficult or laboured respiration)
Gallbladder disorder
Injury
Paranasal sinus hypersecretion

30-39:

Cellulitis (infection under the skin)
Concussion (short loss of normal brain function in response to a head injury)
Fasciitis (infection of muscle surrounding tissue)
Head injury
Injection site infection
Injection site pain
Myositis (inflammation of the muscles)
Anxiety
Conjunctivitis (pink eye)
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection)

40-49:

Corneal dystrophy (abnormal deposition of substances in the transparent front part of the eye)
Insomnia (sleeplessness)
Muscle tightness
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac arrest
Constipation
Drug ineffective
Hypertension (high blood pressure)

50-59:

Drug ineffective
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Dysphagia (a condition in which swallowing is difficult or painful)
Haemoglobin decreased
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Surgery
Arthralgia (joint pain)
Back pain
Depression
Drug hypersensitivity

60+:

Fatigue (feeling of tiredness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Femur fracture
Fluid retention (an abnormal accumulation of fluid in the blood)
Hip fracture
Peripheral swelling
Abdominal pain upper
Aortic arteriosclerosis (hardening of the aortic arteries)
Atrial tachycardia (rhythm disturbance that arises in the atria)
Blood glucose increased

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 33 people, 41.77%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 20 people, 25.32%
Migraine (headache): 8 people, 10.13%
Immunodeficiency Common Variable: 7 people, 8.86%
Drowsiness: 6 people, 7.59%

* Approximation only. Some reports may have incomplete information.

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