Naprosyn and Xyzal drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Naprosyn (naproxen) and Xyzal (levocetirizine dihydrochloride). Common drug interactions include meniscus lesion among females and headache among males.

The phase IV clinical study analyzes what interactions people have when they take Naprosyn and Xyzal. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Naprosyn?

Naprosyn has active ingredients of naproxen. It is often used in pain. eHealthMe is studying from 16,738 Naprosyn users. Check the latest studies of Naprosyn.

What is Xyzal?

Xyzal has active ingredients of levocetirizine dihydrochloride. It is often used in allergies. eHealthMe is studying from 21,479 Xyzal users. Check the latest studies of Xyzal.

On Jul, 20, 2026

41 people who take Naprosyn and Xyzal together, and have interactions are studied.

What are the common drug interactions of Naprosyn and Xyzal, by gender? *:

female:

Meniscus lesion (lesion of a crescent-shaped piece of cartilage between the femur and the tibia)
Muscle atrophy (a decrease in the mass of the muscle)
Muscle injury
Neuropathy peripheral (surface nerve damage)
Oedema peripheral (superficial swelling)
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Pain in extremity
Poor quality sleep
Renal tubular necrosis (death of kidney tubules)

male:

Headache (pain in head)
Muscle strain (an injury to a muscle in which the muscle fibres tear)
Migraine (headache)
Prostate infection
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
Anxiety
Cyst (a closed sac)
Dermal cyst
Hypersensitivity
Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)

What are the common drug interactions of Naprosyn and Xyzal, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Acute sinusitis
Blood glucose increased
Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Injection site pain

20-29:

n/a

30-39:

Autoimmune thyroiditis (form of thyroiditis associated with an autoimmune disease)
Bipolar disorder (mood disorder)
Bone disorder
Depression
Foot fracture
Gastric polyps (abnormal growth of stomach tissue projecting from a mucous membrane)
Gastritis erosive (a break in the surface layer of the membrane lining the stomach with infection)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Muscle spasms (muscle contraction)
Neuropathy peripheral (surface nerve damage)

40-49:

Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Arthralgia (joint pain)
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder)
Dependence
Drug abuse
Drug ineffective
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Eating disorder
Fall
Fatigue (feeling of tiredness)

50-59:

Secondary hyperthyroidism
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Vitiligo (pigment is lost from areas of the skin)
Chronic kidney disease
Glomerulonephritis chronic (long lasting group of conditions that affect parts of the kidneys called glomeruli)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Renal haematoma (blood collection in kidney)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephritic syndrome (a collection of signs (known as a syndrome) associated with disorders affecting the kidneys, more specifically glomerular disorders)

60+:

Cough
Gastrointestinal infection (infection of stomach and intestine)
Migraine (headache)
Prostate infection
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
Anxiety
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Balance disorder
Cardiac valve disease (heart valve disease)
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 9 people, 21.95%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 19.51%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 12.20%
High Blood Cholesterol: 5 people, 12.20%
Sleep Disorder: 4 people, 9.76%
High Blood Pressure: 4 people, 9.76%
Gout (uric acid crystals building up in the body): 4 people, 9.76%
Cardiac Disorder: 4 people, 9.76%
Blood Pressure Abnormal: 4 people, 9.76%
Type 2 Diabetes: 3 people, 7.32%

* Approximation only. Some reports may have incomplete information.

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