Xyzal and Prempro drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Xyzal (levocetirizine dihydrochloride) and Prempro (estrogens, conjugated; medroxyprogesterone acetate). Common drug interactions include kidney infection among females.

The phase IV clinical study analyzes what interactions people have when they take Xyzal and Prempro. It is created by eHealthMe based on reports of 40 people who take the same drugs from the FDA, and is updated regularly.

What is Xyzal?

Xyzal has active ingredients of levocetirizine dihydrochloride. It is often used in allergies. eHealthMe is studying from 21,479 Xyzal users. Check the latest studies of Xyzal.

What is Prempro?

Prempro has active ingredients of estrogens, conjugated; medroxyprogesterone acetate. It is often used in menopause. eHealthMe is studying from 42,950 Prempro users. Check the latest studies of Prempro.

On Jul, 12, 2026

40 people who take Xyzal and Prempro together, and have interactions are studied.

What are the common drug interactions of Xyzal and Prempro, by gender? *:

female:

Kidney infection
Headache (pain in head)
Back pain
Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)
Blood cholesterol increased
Contusion (a type of hematoma of tissue in which capillaries)
Dry mouth
Fatigue (feeling of tiredness)
Fluid overload (too much fluid in the blood)
Hyperhidrosis (abnormally increased sweating)

male:

n/a

What are the common drug interactions of Xyzal and Prempro, by age (0-1 to 60+)? *:

0-1:

Vulvovaginal disorder

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Blood cholesterol increased
Pain
Psychotic disorder
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)
Affect lability (emotional incontinence)
Agitation (state of anxiety or nervous excitement)
Lethargy (tiredness)
Memory impairment
Depression
Bipolar i disorder (mood disorder that is characterized by at least one manic or mixed episode)

40-49:

Blood glucose increased
Blood potassium decreased
Diarrhoea
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Dyspnoea (difficult or laboured respiration)
Nausea (feeling of having an urge to vomit)
Papilloma viral infection
Respiratory tract infection
Respiratory tract infection viral
Vomiting

50-59:

Kidney infection
Sinusitis (inflammation of sinus)
Chronic kidney disease
Headache (pain in head)
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)
Renal disorder (kidney disease)
Dyspnoea (difficult or laboured respiration)
Infusion related reaction
Back pain

60+:

Contusion (a type of hematoma of tissue in which capillaries)
Dry mouth
Chronic kidney disease
Cytomegalovirus infection
Disease recurrence
Drug ineffective
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dry skin
Erythema nodosum (skin inflammation that results in reddish, painful, tender lumps most commonly located in the front of the legs below)
Fall

What are the existing conditions these people have? *

Immunodeficiency Common Variable: 9 people, 22.50%
Insomnia (sleeplessness): 7 people, 17.50%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 15.00%
High Blood Pressure: 4 people, 10.00%
High Blood Cholesterol: 4 people, 10.00%
Pain: 3 people, 7.50%
Depression: 3 people, 7.50%
Migraine (headache): 3 people, 7.50%
Multiple Allergies (allergy to multiple agents): 3 people, 7.50%
Headache (pain in head): 3 people, 7.50%

* Approximation only. Some reports may have incomplete information.

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