Savella and Xyzal drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Savella (milnacipran hydrochloride) and Xyzal (levocetirizine dihydrochloride). Common drug interactions include nephrolithiasis among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Savella and Xyzal. It is created by eHealthMe based on reports of 57 people who take the same drugs from the FDA, and is updated regularly.

What is Savella?

Savella has active ingredients of milnacipran hydrochloride. It is often used in fibromyalgia. eHealthMe is studying from 7,529 Savella users. Check the latest studies of Savella.

What is Xyzal?

Xyzal has active ingredients of levocetirizine dihydrochloride. It is often used in allergies. eHealthMe is studying from 21,479 Xyzal users. Check the latest studies of Xyzal.

On Jul, 14, 2026

57 people who take Savella and Xyzal together, and have interactions are studied.

What are the common drug interactions of Savella and Xyzal, by gender? *:

female:

Nephrolithiasis (calculi in the kidneys)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Urinary tract infection
Vomiting
Barrett's oesophagus (barrett's oesophagus is a disorder in which the lining of the oesophagus (the tube that carries food from the throat to the stomach) is damaged by stomach acid and changed to a lining similar to that of the stomach)
Breast cancer
Drug ineffective
Dry eye (lack of adequate tears)
Ear infection
Gastric dysplasia (stomach with abnormality of development)

male:

Chronic kidney disease
Gout (uric acid crystals building up in the body)
Renal failure (kidney dysfunction)

What are the common drug interactions of Savella and Xyzal, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Angioedema (rapid swelling of the dermis)
Aphthous ulcer (mouth ulcer)
Bone pain
Headache (pain in head)
Kidney infection
Nausea (feeling of having an urge to vomit)
Oral discomfort (pain or irritation in mouth)
Pain in extremity
Migraine (headache)

30-39:

Aortic thrombosis (formation of a blood clot inside aorta)
Blepharospasm (any abnormal contraction or twitch of the eyelid)
Cardiac disorder
Night sweats (sweating in night)
Scar
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Spinal fusion surgery

40-49:

Blood pressure increased
Cataract (clouding of the lens inside the eye)
Overdose
Sinusitis (inflammation of sinus)

50-59:

Drug hypersensitivity
Surgery
Anaphylactic reaction (serious allergic reaction)
Ankle fracture
Cholangitis (infection of the bile duct)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Drug ineffective
Fall
Fibula fracture
Foot fracture

60+:

Concussion (short loss of normal brain function in response to a head injury)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Injection site haemorrhage (bleeding from injection site)
Renal failure (kidney dysfunction)
Head injury
Infusion site haemorrhage (bleeding from infusion site)
Nausea (feeling of having an urge to vomit)
Rectal haemorrhage (bleeding from anus)
Chronic kidney disease
Gout (uric acid crystals building up in the body)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 22 people, 38.60%
Asthma: 12 people, 21.05%
Immunodeficiency Common Variable: 8 people, 14.04%
Primary Immunodeficiency Syndrome: 7 people, 12.28%
Pain: 7 people, 12.28%
Migraine (headache): 6 people, 10.53%
Hypersensitivity: 6 people, 10.53%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 6 people, 10.53%
Seasonal Allergy (allergic condition due to certain season): 5 people, 8.77%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 8.77%

* Approximation only. Some reports may have incomplete information.

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