Xyzal and Zosyn drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Xyzal (levocetirizine dihydrochloride) and Zosyn (piperacillin sodium; tazobactam sodium). Common drug interactions include hypersensitivity among females and sepsis among males.

The phase IV clinical study analyzes what interactions people have when they take Xyzal and Zosyn. It is created by eHealthMe based on reports of 37 people who take the same drugs from the FDA, and is updated regularly.

What is Xyzal?

Xyzal has active ingredients of levocetirizine dihydrochloride. It is often used in allergies. eHealthMe is studying from 21,479 Xyzal users. Check the latest studies of Xyzal.

What is Zosyn?

Zosyn has active ingredients of piperacillin sodium; tazobactam sodium. It is often used in pneumonia. eHealthMe is studying from 10,236 Zosyn users. Check the latest studies of Zosyn.

On Jul, 13, 2026

37 people who take Xyzal and Zosyn together, and have interactions are studied.

What are the common drug interactions of Xyzal and Zosyn, by gender? *:

female:

Hypersensitivity
Interstitial lung disease
Oxygen saturation decreased
Pain in jaw
Pharyngeal oedema (abnormal accumulation of fluid in the cavities and intercellular spaces of the pharyngeal)
Pneumonia bacterial (pneumonia associated with bacterial infection)
Respiratory distress (difficulty in breathing)
Sputum retention
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Wheezing (a high-pitched whistling sound made while you breath)

male:

Sepsis (a severe blood infection that can lead to organ failure and death)
Electrolyte imbalance
Osteonecrosis (death of bone)
Pelvic abscess
Perirectal abscess
Platelet count decreased
Procedural pain
Pulmonary function test decreased
Pyrexia (fever)
Rectal abscess (pus in rectum)

What are the common drug interactions of Xyzal and Zosyn, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Anal fistula
Blepharitis (chronic inflammation of the eyelid)
Cerebral infarction (less blood supply to brain resulting tissue damage)
Sepsis (a severe blood infection that can lead to organ failure and death)
Abscess (pus)
Appendicitis perforated (perforated appendicitis is a condition in which an inflamed appendix bursts)
Blood sodium decreased
Drug eruption (adverse drug reaction of the skin)
Drug hypersensitivity
Electrolyte imbalance

20-29:

n/a

30-39:

n/a

40-49:

Chronic kidney disease
Renal failure (kidney dysfunction)

50-59:

Abdominal distension
Anaphylactic reaction (serious allergic reaction)
Asthma
Bronchiectasis (abnormal widening of the bronchi or their branches, causing a risk of infection)
Catheter site pain
Catheter site swelling
Diarrhoea
Drug hypersensitivity
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)

60+:

Diarrhoea
Cardiac failure
Injection site erythema (redness at injection site)
Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
Oedema peripheral (superficial swelling)
Oesophageal rupture (break in oesophagus)
Pleural effusion (water on the lungs)
Relapsing fever (bacterial infection characterized by recurring episodes of fever, headache, muscle and joint aches, and nausea)
Spinal compression fracture (fracture due to spinal compression on bone)
Hypokalaemia (low potassium)

What are the existing conditions these people have? *

Insomnia (sleeplessness): 15 people, 40.54%
Febrile Neutropenia (fever with reduced white blood cells): 11 people, 29.73%
Rashes (redness): 10 people, 27.03%
Pneumonia: 10 people, 27.03%
Adult T-Cell Lymphoma/leukaemia (cancer of the immune system's own t-cells): 10 people, 27.03%
Fever: 10 people, 27.03%
Oedema Peripheral (superficial swelling): 8 people, 21.62%
Type 2 Diabetes: 6 people, 16.22%
High Blood Pressure: 6 people, 16.22%
Non-Small Cell Lung Cancer Recurrent (type of epithelial lung cancer reoccurrence): 6 people, 16.22%

* Approximation only. Some reports may have incomplete information.

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