Yaz and Ultracet drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Yaz (drospirenone; ethinyl estradiol) and Ultracet (acetaminophen; tramadol hydrochloride). Common drug interactions include convulsion among females and deep vein thrombosis among males.

The phase IV clinical study analyzes what interactions people have when they take Yaz and Ultracet. It is created by eHealthMe based on reports of 68 people who take the same drugs from the FDA, and is updated regularly.

What is Yaz?

Yaz has active ingredients of drospirenone; ethinyl estradiol. It is often used in birth control. eHealthMe is studying from 41,514 Yaz users. Check the latest studies of Yaz.

What is Ultracet?

Ultracet has active ingredients of acetaminophen; tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 6,351 Ultracet users. Check the latest studies of Ultracet.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

68 people who take Yaz and Ultracet together, and have interactions are studied.

What are the common drug interactions of Yaz and Ultracet, by gender? *:

female:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Dry eye (lack of adequate tears)
Dyspnoea exertional (breathlessness or shortness of breath)
Embolism arterial (blood clot that has travelled through your arteries and become stuck)
Epigastric discomfort
Flatulence (flatus expelled through the anus)
Frustration (a form of poorly expressed anger)
Gallbladder pain
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Hyperhidrosis (abnormally increased sweating)

male:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Injury
Pallor
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin)
Anxiety
Burkitt's lymphoma (cancer of the lymphatic system)
Emotional distress
General physical health deterioration (weak health status)
Neutropenia (an abnormally low number of neutrophils)
Neutrophil count increased (excess than normal number of neutrophil a type of blood cell)

What are the common drug interactions of Yaz and Ultracet, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Anxiety
Injury
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Emotional distress
Fear of disease
Pain in extremity
Pulmonary embolism (blockage of the main artery of the lung)
Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)

30-39:

Nausea (feeling of having an urge to vomit)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Pain in extremity
Diarrhoea
Abdominal pain
Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Asthenia (weakness)
Decreased appetite
Decreased interest

40-49:

Palpitations (feelings or sensations that your heart is pounding or racing)
Postictal state
Pulmonary infarction (death of a small area of lung)
Pyrexia (fever)
Rash
Sensation of heaviness
Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)
Vein disorder
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Injury

50-59:

Gallbladder disorder
Injury
Abdominal pain
Cholecystitis chronic (long lasting infection of gallbladder)
Emotional distress
General physical health deterioration (weak health status)
Cough
Dizziness
Dysphonia (speech disorder attributable to a disorder of phonation)
Dyspnoea (difficult or laboured respiration)

60+:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Injury
Pulmonary embolism (blockage of the main artery of the lung)
Pulmonary infarction (death of a small area of lung)
Renal impairment (severely reduced kidney function)
Venous injury
White blood cell count decreased
White blood cell count increased
Anxiety
Burkitt's lymphoma (cancer of the lymphatic system)

What are the existing conditions these people have? *

Acne (skin problems that cause pimples): 15 people, 22.06%
Premenstrual Syndrome: 8 people, 11.76%
High Blood Pressure: 7 people, 10.29%
Incontinence (lack of moderation or self-control): 6 people, 8.82%
Diabetes: 6 people, 8.82%
Stress And Anxiety: 5 people, 7.35%
Headache (pain in head): 5 people, 7.35%
Multiple Allergies (allergy to multiple agents): 4 people, 5.88%
Migraine (headache): 4 people, 5.88%

* Approximation only. Some reports may have incomplete information.

Do you take Yaz and Ultracet?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously