Yaz and Zopiclone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Yaz (drospirenone; ethinyl estradiol) and Zopiclone (eszopiclone). Common drug interactions include hypogammaglobulinaemia among females and headache among males.

The phase IV clinical study analyzes what interactions people have when they take Yaz and Zopiclone. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Yaz?

Yaz has active ingredients of drospirenone; ethinyl estradiol. It is often used in birth control. eHealthMe is studying from 41,514 Yaz users. Check the latest studies of Yaz.

What is Zopiclone?

Zopiclone has active ingredients of eszopiclone. It is often used in insomnia. eHealthMe is studying from 54,331 Zopiclone users. Check the latest studies of Zopiclone.

On Aug, 01, 2026

18 people who take Yaz and Zopiclone together, and have interactions are studied.

What are the common drug interactions of Yaz and Zopiclone, by gender? *:

female:

Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection)
Iron deficiency
Iron deficiency anaemia
Lateral medullary syndrome (neurologic symptoms due to injury to the lateral part of the medulla in the brain)
Lymphangiectasia (a disease of the lymphatic vessels that results in the leakage of protein-rich lymph)
Malabsorption (a state arising from abnormality in absorption of food nutrients across the gastrointestinal (gi) tract)
Mean cell volume decreased (less of the average red blood cell volume)
Migraine (headache)
Monocyte count increased
Neutrophil count increased (excess than normal number of neutrophil a type of blood cell)

male:

Headache (pain in head)
Injury
Cough
Dizziness
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Fear
Hyperventilation
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Palpitations (feelings or sensations that your heart is pounding or racing)

What are the common drug interactions of Yaz and Zopiclone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal pain upper
Asthenia (weakness)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Cholecystitis chronic (long lasting infection of gallbladder)
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Depression
Dizziness
Fatigue (feeling of tiredness)
Gallbladder disorder
Haemoglobin decreased

20-29:

Wound secretion
Abdominal pain upper
Anaemia (lack of blood)
Asthenia (weakness)
Back pain
Blood albumin decreased
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Headache (pain in head)
Heart rate increased
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection)

30-39:

Injury
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Blood pressure fluctuation
Hypoaesthesia (reduced sense of touch or sensation)
Visual acuity reduced (reduced clearness of vision)
Visual impairment
White blood cell count decreased
Chest pain
Pulmonary embolism (blockage of the main artery of the lung)
Pain

40-49:

Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Injury
Pain

50-59:

n/a

60+:

Aphasia (damage to the parts of the brain that control language)
Headache (pain in head)
Injury
Pain
Pulmonary embolism (blockage of the main artery of the lung)
Pulmonary infarction (death of a small area of lung)
Arthralgia (joint pain)
Blood immunoglobulin g increased
Bone pain
Cholecystitis (infection of gallbladder)

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 27.78%
Acne (skin problems that cause pimples): 3 people, 16.67%
Premenstrual Syndrome: 3 people, 16.67%
Depression: 3 people, 16.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 11.11%
Juvenile Rheumatoid Arthritis (joint inflammation in children due to systemic disease): 2 people, 11.11%
Pain: 2 people, 11.11%
Bipolar Disorder (mood disorder): 2 people, 11.11%
Colon Cancer: 1 person, 5.56%
Bone Pain: 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

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