Zaroxolyn and Marcaine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zaroxolyn (metolazone) and Marcaine (bupivacaine hydrochloride). Common drug interactions include chronic obstructive pulmonary disease among females and emotional distress among males.

The phase IV clinical study analyzes what interactions people have when they take Zaroxolyn and Marcaine. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Zaroxolyn?

Zaroxolyn has active ingredients of metolazone. It is often used in high blood pressure. eHealthMe is studying from 5,244 Zaroxolyn users. Check the latest studies of Zaroxolyn.

What is Marcaine?

Marcaine has active ingredients of bupivacaine hydrochloride. It is often used in pain. eHealthMe is studying from 4,026 Marcaine users. Check the latest studies of Marcaine.

On Jul, 21, 2026

14 people who take Zaroxolyn and Marcaine together, and have interactions are studied.

Zaroxolyn and Marcaine drug interactions.

What are the common drug interactions of Zaroxolyn and Marcaine, by gender? *:

female:

Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Clostridium test positive
Diarrhoea
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)
Fatigue (feeling of tiredness)
Fluid overload (too much fluid in the blood)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)

male:

Emotional distress
Injury
Hypoxia (low oxygen in tissues)
Pancreatitis (inflammation of pancreas)
Pleural effusion (water on the lungs)
Pyrexia (fever)
Rash
Abdominal infection
Activated partial thromboplastin time prolonged
Alanine aminotransferase increased

What are the common drug interactions of Zaroxolyn and Marcaine, by age (0-1 to 60+)? *:

0-1:

Abdominal infection
Activated partial thromboplastin time prolonged
Alanine aminotransferase increased
Ammonia decreased
Anaemia (lack of blood)
Anion gap increased
Aspartate aminotransferase increased
Blast cell count increased
Blood albumin decreased
Blood calcium decreased

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Stress
Anxiety
Emotional distress
Fear
Injury
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)
Renal injury (kidney injury)

60+:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Hypotension (abnormally low blood pressure)
Oedema peripheral (superficial swelling)
Renal failure (kidney dysfunction)
Cardiac disorder
Cardiac failure
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Clostridium test positive
Diarrhoea

What are the existing conditions these people have? *

Type 2 Diabetes: 5 people, 35.71%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 5 people, 35.71%
Cardiomyopathy (weakening of the heart muscle): 1 person, 7.14%
Acute Leukaemia (blood cancer): 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Zaroxolyn and Marcaine?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously