Zelboraf and Paracetamol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zelboraf (vemurafenib) and Paracetamol (acetaminophen). Common drug interactions include diarrhoea among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Zelboraf and Paracetamol. It is created by eHealthMe based on reports of 70 people who take the same drugs from the FDA, and is updated regularly.

What is Zelboraf?

Zelboraf has active ingredients of vemurafenib. eHealthMe is studying from 8,392 Zelboraf users. Check the latest studies of Zelboraf.

What is Paracetamol?

Paracetamol has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 115,650 Paracetamol users. Check the latest studies of Paracetamol.

On Jul, 27, 2026

70 people who take Zelboraf and Paracetamol together, and have interactions are studied.

Zelboraf and Paracetamol drug interactions.

What are the common drug interactions of Zelboraf and Paracetamol, by gender? *:

female:

Diarrhoea
Eosinophilia (eosinophil count in the peripheral blood exceeds)
Erythema multiforme (a type of hypersensitivity reaction)
Eye swelling
Inflammatory marker increased
Influenza
Lip swelling
Oral candidiasis (fungal infection of mouth)
Pneumonia
Pneumonitis (inflammation of the walls of the alveoli in the lungs)

male:

Dyspnoea (difficult or laboured respiration)
Vomiting
Hyperglycaemia (high blood sugar)
Hyperthyroidism (over activity of the thyroid gland)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Myalgia (muscle pain)
Myopia (difficult to see objects that are far away)
Oral candidiasis (fungal infection of mouth)
Oral herpes (viral infection of mouth)
Upper respiratory tract infection

What are the common drug interactions of Zelboraf and Paracetamol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Hepatocellular injury (liver injury)
Jaundice cholestatic
Burning sensation
Erythema (redness of the skin)
Pericarditis (inflammation of the pericardium)

30-39:

Abdominal pain upper
Arthralgia (joint pain)
Bile duct stone
Cough
Disease progression
Haematochezia (passage of stools containing blood)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Hyperkeratosis (thickening of the outer layer of the skin)
Lymphadenopathy mediastinal (an enlargement of the lymph nodes in the part of the chest that separates the lungs)
Metastases to lung (cancer spreads to lung)

40-49:

Cerebral haemorrhage (bleeding within the brain)
Generalised oedema (swelling all over the body)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Thermal burn (burn by heat)
Alopecia (absence of hair from areas of the body)
Arthralgia (joint pain)
Dermatitis acneiform (dermatoses including acne vulgaris, rosacea, folliculitis, and perioral dermatitis)
Diarrhoea
Dysphagia (a condition in which swallowing is difficult or painful)
Induration (thickening of tissue)

50-59:

Acute generalised exanthematous pustulosis (acute febrile drug eruption)
Eosinophilia (eosinophil count in the peripheral blood exceeds)
Erythema (redness of the skin)
Face oedema (swelling of face)
Pruritus (severe itching of the skin)
Anuria (failure of the kidneys to produce urine)
C-reactive protein increased
Disturbance in attention
Drug eruption (adverse drug reaction of the skin)
General physical health deterioration (weak health status)

60+:

Vomiting
Dyspnoea (difficult or laboured respiration)
Fall
General physical health deterioration (weak health status)
Hyperglycaemia (high blood sugar)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Myalgia (muscle pain)
Myopia (difficult to see objects that are far away)
Oral herpes (viral infection of mouth)
Upper respiratory tract infection

What are the existing conditions these people have? *

Malignant Melanoma (skin cancer rises from melancytes): 31 people, 44.29%
Metastatic Malignant Melanoma (spreadable cancer tumour of melanine): 27 people, 38.57%
High Blood Pressure: 12 people, 17.14%
Metastases To Central Nervous System (cancer spreads to central nervous system): 8 people, 11.43%
Constipation: 8 people, 11.43%
Neoplasm Malignant (cancer tumour): 7 people, 10.00%
Thrombosis (formation of a blood clot inside a blood vessel): 6 people, 8.57%
Malignant Melanoma Stage Iv (the cancer has spread to other places in the body, such as the lung, liver, brain, bone, soft tissue, or gastrointestinal (gi) tract. cancer may have spread to places in the skin far away from where it first started): 4 people, 5.71%

* Approximation only. Some reports may have incomplete information.

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