Zelnorm and Aldactone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zelnorm (tegaserod maleate) and Aldactone (spironolactone). Common drug interactions include umbilical hernia among females and abdominal pain among males.

The phase IV clinical study analyzes what interactions people have when they take Zelnorm and Aldactone. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.

What is Zelnorm?

Zelnorm has active ingredients of tegaserod maleate. eHealthMe is studying from 7,261 Zelnorm users. Check the latest studies of Zelnorm.

What is Aldactone?

Aldactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 46,063 Aldactone users. Check the latest studies of Aldactone.

On Jul, 21, 2026

41 people who take Zelnorm and Aldactone together, and have interactions are studied.

Zelnorm and Aldactone drug interactions.

What are the common drug interactions of Zelnorm and Aldactone, by gender? *:

female:

Umbilical hernia (an outward bulging (protrusion) of the abdominal lining or part of the abdominal organ(s) through the area around the belly button)
Upper respiratory tract infection
Ventricular hypertrophy (enlargement of ventricles (lower chambers) in the heart)
Vocal cord polyp
Weight bearing difficulty (difficulty due to weight of thigh fat deposition)
Actinomycosis (infection that causes sores, or abscesses)
Angiopathy (generic term for a disease of the blood vessels)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Bacteraemia (presence of bacteria in the blood)
Bone disorder

male:

Abdominal pain
Anaemia (lack of blood)
Dizziness
Dyspnoea (difficult or laboured respiration)
Emotional distress
Fatigue (feeling of tiredness)
Gastroenteritis (inflammation of stomach and intestine)
Headache (pain in head)
Hip fracture
Hyperhidrosis (abnormally increased sweating)

What are the common drug interactions of Zelnorm and Aldactone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Cardiac disorder
Migraine (headache)
Type 1 diabetes mellitus
Cardiac failure congestive
Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Hypoglycaemia (deficiency of glucose in the bloodstream)
Joint injury
Thrombosis (formation of a blood clot inside a blood vessel)

30-39:

Cholecystitis (infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetes mellitus inadequate control
Diabetic gastroparesis (paralysis of the muscles of the stomach caused by diabetes)
Diarrhoea
Gallbladder operation
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Ill-defined disorder
Thyroid operation

40-49:

Anxiety
Back pain
Dyspnoea (difficult or laboured respiration)
Ear pain
Pain
Pain in extremity
Sinus bradycardia (an unusually slow heartbeat due to heart disease)
Sinusitis (inflammation of sinus)
Abdominal discomfort
Anaemia (lack of blood)

50-59:

Anaemia (lack of blood)
Cardiac failure congestive
Diarrhoea
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Emotional distress
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Nausea (feeling of having an urge to vomit)
Oedema peripheral (superficial swelling)
Pruritus (severe itching of the skin)
Abdominal pain upper

60+:

Abdominal pain lower
Intestinal perforation (complete penetration of the wall of the intestine)
Pseudomonas infection (pseudomonas infection is caused by a bacterium, pseudomonas aeruginosa)
Respiratory tract infection
Rhonchi (abnormal breath sounds)
Sputum culture positive
Staphylococcal infection (an infection with staphylococcus bacteria)
Surgery
Wheezing (a high-pitched whistling sound made while you breath)
Blood pressure decreased

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 10 people, 24.39%
Pain: 9 people, 21.95%
Multiple Myeloma (cancer of the plasma cells): 7 people, 17.07%
Irritable Bowel Syndrome: 7 people, 17.07%
High Blood Pressure: 7 people, 17.07%
Fatigue (feeling of tiredness): 7 people, 17.07%
Breast Cancer Metastatic: 5 people, 12.20%
Osteoporosis (bones weak and more likely to break): 4 people, 9.76%
Constipation: 4 people, 9.76%
Reflux Oesophagitis (an oesophageal mucosal injury that occurs of gastric contents into the oesophagus): 3 people, 7.32%

* Approximation only. Some reports may have incomplete information.

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