Zelnorm and Yaz drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zelnorm (tegaserod maleate) and Yaz (drospirenone; ethinyl estradiol). Common drug interactions include cholelithiasis among females and asthma among males.

The phase IV clinical study analyzes what interactions people have when they take Zelnorm and Yaz. It is created by eHealthMe based on reports of 46 people who take the same drugs from the FDA, and is updated regularly.

What is Zelnorm?

Zelnorm has active ingredients of tegaserod maleate. eHealthMe is studying from 7,261 Zelnorm users. Check the latest studies of Zelnorm.

What is Yaz?

Yaz has active ingredients of drospirenone; ethinyl estradiol. It is often used in birth control. eHealthMe is studying from 41,514 Yaz users. Check the latest studies of Yaz.

On Jul, 17, 2026

46 people who take Zelnorm and Yaz together, and have interactions are studied.

What are the common drug interactions of Zelnorm and Yaz, by gender? *:

female:

Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Cholecystitis chronic (long lasting infection of gallbladder)
Injury
Pain
Abdominal pain
Abdominal pain upper
Pulmonary embolism (blockage of the main artery of the lung)
Arterial thrombosis limb (formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system-limb)
Gallbladder disorder
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

male:

Asthma
Bone marrow failure
Abdominal pain
Ascites (accumulation of fluid in the abdominal cavity)
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Blood creatinine increased
Candida sepsis (candida in blood stream)
Complications of transplanted kidney
Loss of consciousness
Peritoneal candidiasis (fungal infection in peritoneal)

What are the common drug interactions of Zelnorm and Yaz, by age (0-1 to 60+)? *:

0-1:

Abdominal pain
Ascites (accumulation of fluid in the abdominal cavity)
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Blood creatinine increased
Candida sepsis (candida in blood stream)
Complications of transplanted kidney
Loss of consciousness
Peritoneal candidiasis (fungal infection in peritoneal)
Post procedural infection
Septic shock (shock due to blood infection)

2-9:

n/a

10-19:

Injury
Arterial thrombosis limb (formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system-limb)
Abdominal pain
Abdominal pain upper
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Cholesterosis (abnormal deposition of cholesterol in tissues)

20-29:

Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Pain
Abdominal pain upper
Injury
Abdominal tenderness
Constipation
Diverticulum (out pouching of a hollow (or a fluid-filled) structure in the body)
Gallbladder disorder
Abdominal pain

30-39:

Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Cholecystitis chronic (long lasting infection of gallbladder)
Weight decreased
Abdominal pain
Vaginal haemorrhage (vaginal bleeding)
Abdominal pain upper
Biliary dyskinesia (motility disorder that affects the gallbladder and sphincter of oddi)
Blindness unilateral
Cerebral infarction (less blood supply to brain resulting tissue damage)
Dysarthria (speech disorder)

40-49:

Chest pain
Dyspnoea (difficult or laboured respiration)
Pulmonary embolism (blockage of the main artery of the lung)
Asthma
Cholecystitis chronic (long lasting infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Gallbladder cholesterolosis (accumulation and deposition of cholesterol inside of the)
Gallbladder injury
Lung neoplasm (tumour of lung)
Abdominal pain

50-59:

Asthma
Bone marrow failure
Chest pain
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it)
Dyspnoea (difficult or laboured respiration)
General physical health deterioration (weak health status)
Lung neoplasm (tumour of lung)
Mucosal inflammation (infection of mucous membrane)
Neoplasm progression (growth of tumour)
Pulmonary embolism (blockage of the main artery of the lung)

60+:

n/a

What are the existing conditions these people have? *

Acne (skin problems that cause pimples): 9 people, 19.57%
Premenstrual Syndrome: 8 people, 17.39%
Constipation: 7 people, 15.22%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 6 people, 13.04%
Depression: 5 people, 10.87%
Menstruation Irregular: 5 people, 10.87%
Irritable Bowel Syndrome: 5 people, 10.87%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 8.70%
Ovarian Cysts (fluid filled sacs of the ovary): 4 people, 8.70%
Herpes Virus Infection: 3 people, 6.52%

* Approximation only. Some reports may have incomplete information.

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