Zemplar and Rapamune drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zemplar (paricalcitol) and Rapamune (sirolimus). Common drug interactions include white blood cell count increased among females and discomfort among males.

The phase IV clinical study analyzes what interactions people have when they take Zemplar and Rapamune. It is created by eHealthMe based on reports of 42 people who take the same drugs from the FDA, and is updated regularly.

What is Zemplar?

Zemplar has active ingredients of paricalcitol. It is often used in kidney disease. eHealthMe is studying from 15,494 Zemplar users. Check the latest studies of Zemplar.

What is Rapamune?

Rapamune has active ingredients of sirolimus. It is often used in kidney transplant. eHealthMe is studying from 13,848 Rapamune users. Check the latest studies of Rapamune.

On Jul, 15, 2026

42 people who take Zemplar and Rapamune together, and have interactions are studied.

What are the common drug interactions of Zemplar and Rapamune, by gender? *:

female:

White blood cell count increased
Abdominal pain
Chest pain
Dizziness
Dysphagia (a condition in which swallowing is difficult or painful)
Fluid retention (an abnormal accumulation of fluid in the blood)
Hypotension (abnormally low blood pressure)
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Pleural effusion (water on the lungs)

male:

Discomfort
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Mobility decreased (ability to move is reduced)
Muscular weakness (muscle weakness)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nausea (feeling of having an urge to vomit)
Pruritus (severe itching of the skin)
Scar
Skin discolouration (change of skin colour)
Skin fissures (a crack in the skin)

What are the common drug interactions of Zemplar and Rapamune, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Bacterial infection
Chest pain
Chills (felling of cold)
Diarrhoea
Fatigue (feeling of tiredness)
Hyperkalaemia (damage to or disease of the kidney)
Hypotension (abnormally low blood pressure)
Hypoxia (low oxygen in tissues)
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)

20-29:

n/a

30-39:

Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Fatigue (feeling of tiredness)
Fluid retention (an abnormal accumulation of fluid in the blood)
Haemoglobin increased
Haemolysis (breaking open of red blood cells and the release of haemoglobin into the surrounding fluid)
Platelet count increased
Pyrexia (fever)
Red blood cell count decreased

40-49:

Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Anxiety
Asthenia (weakness)
Back pain
Balance disorder
Deformity (disfigurement)
Emotional distress
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
Gait disturbance
General physical health deterioration (weak health status)

50-59:

General physical health deterioration (weak health status)
Joint range of motion decreased (disease of joint movement)
Joint stiffness
Mobility decreased (ability to move is reduced)
Muscular weakness (muscle weakness)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nausea (feeling of having an urge to vomit)
Oedema peripheral (superficial swelling)
Pruritus (severe itching of the skin)
Scar

60+:

C-reactive protein increased
Infectious peritonitis (inflammation of the peritoneum, typically caused by bacterial infection)
Fatigue (feeling of tiredness)
General physical health deterioration (weak health status)
Pleural effusion (water on the lungs)
Pyrexia (fever)
Renal failure chronic (long lasting kidney dysfunction)
Abdominal discomfort
Anaemia haemolytic autoimmune (a condition in which the immune system attacks the red blood cells, resulting in fewer of these oxygen-transporting cells)
Angioplasty

What are the existing conditions these people have? *

High Blood Cholesterol: 10 people, 23.81%
Hyperparathyroidism Secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary): 8 people, 19.05%
Chronic Renal Failure (kidney failure): 8 people, 19.05%
Blood Phosphorus Increased: 8 people, 19.05%
High Blood Pressure: 5 people, 11.90%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 4 people, 9.52%

* Approximation only. Some reports may have incomplete information.

Do you take Zemplar and Rapamune?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously