Zestoretic and Glucovance drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zestoretic (hydrochlorothiazide; lisinopril) and Glucovance (glyburide; metformin hydrochloride). Common drug interactions include anaemia neonatal among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Zestoretic and Glucovance. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Zestoretic?

Zestoretic has active ingredients of hydrochlorothiazide; lisinopril. It is often used in high blood pressure. eHealthMe is studying from 4,342 Zestoretic users. Check the latest studies of Zestoretic.

What is Glucovance?

Glucovance has active ingredients of glyburide; metformin hydrochloride. It is often used in diabetes. eHealthMe is studying from 6,302 Glucovance users. Check the latest studies of Glucovance.

On Aug, 04, 2026

48 people who take Zestoretic and Glucovance together, and have interactions are studied.

Zestoretic and Glucovance drug interactions.

What are the common drug interactions of Zestoretic and Glucovance, by gender? *:

female:

Anaemia neonatal
Anxiety
Asthenia (weakness)
Blood creatinine increased
Blood disorder
C-reactive protein increased
Cholesteatoma (abnormal skin growth in the middle ear behind the eardrum)
Confusion
Conjunctivitis (pink eye)
Constipation

male:

Dyspnoea (difficult or laboured respiration)
Abdominal pain
5-hydroxyindolacetic acid in urine increased (increased serotonin levels)
Abdominal discomfort
Abdominal distension
Abdominal mass (localized enlargement or swelling in the human abdomen)
Abdominal pain upper
Arthralgia (joint pain)
Blood chromogranin a increased
Blood glucose fluctuation

What are the common drug interactions of Zestoretic and Glucovance, by age (0-1 to 60+)? *:

0-1:

Anaemia neonatal
Blood creatinine increased
Blood urea increased
Cholesteatoma (abnormal skin growth in the middle ear behind the eardrum)
Conjunctivitis (pink eye)
Craniosynostosis (a baby is born with an abnormally shaped skull or develops one during growth)
Deafness
Foetal distress syndrome (altered heart rate or rhythm and leading tocompromised blood flow or changes in blood chemistry of foetus)
Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)
Hyperbilirubinaemia neonatal (excess of bilirubin in the blood in newborn)

2-9:

n/a

10-19:

n/a

20-29:

Anxiety
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Cholecystitis acute (rapid infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Diarrhoea
Discomfort
Ear infection
Emotional distress
Haematoma (collection of blood outside the blood vessels)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)

30-39:

Fluid retention (an abnormal accumulation of fluid in the blood)
Oedema peripheral (superficial swelling)
Skin tightness
Weight increased

40-49:

Acute myocardial infarction (acute heart attack)
Affect lability (emotional incontinence)
Alopecia (absence of hair from areas of the body)
Anxiety
Bacterial infection
Bipolar disorder (mood disorder)
Constipation
Crying
Depression
Dysgeusia (disorder of the sense of taste)

50-59:

Headache (pain in head)
Hyperhidrosis (abnormally increased sweating)
Hypotension (abnormally low blood pressure)
Iiird nerve paralysis (totally closed eyelid and a down and out deviation of the eye)
Ischaemic neuropathy (functional disturbance or pathological change in the peripheral nervous system due to inadequate supply of blood)
Limb discomfort (discomfort in leg)
Muscle cramp (painful sensation caused by muscle contraction)
Myopathy (a muscular disease in which the muscle fibres do not function)
Myositis (inflammation of the muscles)
Oedema (fluid collection in tissue)

60+:

Nausea (feeling of having an urge to vomit)
Abdominal pain
Fatigue (feeling of tiredness)
Hypotension (abnormally low blood pressure)
Loss of consciousness
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Oropharyngeal blistering (blister of oropharynx)
Pain
Pain in extremity
Pitting oedema (skin discoloration)

What are the existing conditions these people have? *

Type 2 Diabetes: 11 people, 22.92%
Depression: 6 people, 12.50%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 10.42%
Sleep Disorder: 4 people, 8.33%
Pelvic Discomfort: 4 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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