Zestoretic and Halcion drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zestoretic (hydrochlorothiazide; lisinopril) and Halcion (triazolam). Common drug interactions include gastrointestinal haemorrhage among females and confusional state among males.

The phase IV clinical study analyzes what interactions people have when they take Zestoretic and Halcion. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Zestoretic?

Zestoretic has active ingredients of hydrochlorothiazide; lisinopril. It is often used in high blood pressure. eHealthMe is studying from 4,342 Zestoretic users. Check the latest studies of Zestoretic.

What is Halcion?

Halcion has active ingredients of triazolam. It is often used in insomnia. eHealthMe is studying from 8,268 Halcion users. Check the latest studies of Halcion.

On Aug, 03, 2026

11 people who take Zestoretic and Halcion together, and have interactions are studied.

Zestoretic and Halcion drug interactions.

What are the common drug interactions of Zestoretic and Halcion, by gender? *:

female:

Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Gastrointestinal ulcer perforation (an opening through a ulcer in digestive tract)
Haemoglobin decreased
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Renal failure (kidney dysfunction)
Weakness
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Pancreatitis (inflammation of pancreas)
Cholecystitis (infection of gallbladder)
Faecal occult blood positive

male:

Confusional state
Agitation (state of anxiety or nervous excitement)
Decreased appetite
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Death
Disorientation (disability in which the senses of time, direction, and recognition of people and places)

What are the common drug interactions of Zestoretic and Halcion, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Pancreatitis (inflammation of pancreas)

60+:

Confusional state
Agitation (state of anxiety or nervous excitement)
Gastrointestinal ulcer perforation (an opening through a ulcer in digestive tract)
Haemoglobin decreased
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pancreatitis (inflammation of pancreas)
Renal failure (kidney dysfunction)
Weakness
Decreased appetite
Tachycardia (a heart rate that exceeds the range of 100 beats/min)

What are the existing conditions these people have? *

Hepatic Neoplasm Malignant (liver cancer): 8 people, 72.73%
Enlarged Prostate: 8 people, 72.73%
Diabetes: 8 people, 72.73%
Oesophagitis (inflammation of oesophagus): 7 people, 63.64%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 7 people, 63.64%
Abdominal Pain: 7 people, 63.64%
Weight Loss: 1 person, 9.09%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 1 person, 9.09%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 9.09%
Fluid Retention (an abnormal accumulation of fluid in the blood): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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