Zestoretic and Lopid drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zestoretic (hydrochlorothiazide; lisinopril) and Lopid (gemfibrozil). Common drug interactions include obsessive-compulsive disorder among females and atrial fibrillation among males.

The phase IV clinical study analyzes what interactions people have when they take Zestoretic and Lopid. It is created by eHealthMe based on reports of 36 people who take the same drugs from the FDA, and is updated regularly.

What is Zestoretic?

Zestoretic has active ingredients of hydrochlorothiazide; lisinopril. It is often used in high blood pressure. eHealthMe is studying from 4,342 Zestoretic users. Check the latest studies of Zestoretic.

What is Lopid?

Lopid has active ingredients of gemfibrozil. It is often used in high blood cholesterol. eHealthMe is studying from 9,700 Lopid users. Check the latest studies of Lopid.

On Jul, 11, 2026

36 people who take Zestoretic and Lopid together, and have interactions are studied.

What are the common drug interactions of Zestoretic and Lopid, by gender? *:

female:

Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Pain
Pain in extremity
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Pregnancy
Productive cough
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Skin exfoliation (removal of the oldest dead skin cells)
Sputum discoloured

male:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Myositis (inflammation of the muscles)
Limb discomfort (discomfort in leg)
Neutropenia (an abnormally low number of neutrophils)
Pain in extremity
Palpitations (feelings or sensations that your heart is pounding or racing)
Venous thrombosis limb (blood clot that forms in a vein in the limb)
Cardiac fibrillation (uncontrolled muscle contraction of heart)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Gout (uric acid crystals building up in the body)

What are the common drug interactions of Zestoretic and Lopid, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cardiac fibrillation (uncontrolled muscle contraction of heart)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Weight increased
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiogenic shock (inadequate circulation of blood)
Death
Diarrhoea
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

50-59:

Myositis (inflammation of the muscles)
Limb discomfort (discomfort in leg)
Gout (uric acid crystals building up in the body)
Hyperlipidaemia (presence of excess lipids in the blood)
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)
Varicose vein (veins that have become enlarged and tortuous)
Abdominal pain upper
Alopecia (absence of hair from areas of the body)
Anxiety
Appetite decreased (decreased appetite occurs when you have a reduced desire to eat)

60+:

Decreased appetite
Dyspnoea (difficult or laboured respiration)
Epistaxis (bleed from the nose)
Fatigue (feeling of tiredness)
Incision site haemorrhage (bleeding from incision site)
Interstitial lung disease
Lactic acidosis (low ph in body tissues)
Myositis (inflammation of the muscles)
Neutropenia (an abnormally low number of neutrophils)
Pain in extremity

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 3 people, 8.33%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 8.33%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 2 people, 5.56%
Stress And Anxiety: 2 people, 5.56%
Pleural Mesothelioma Malignant (cancer of the pleura, or the membrane that lines the lungs): 2 people, 5.56%
Nausea And Vomiting: 2 people, 5.56%
Bipolar Disorder (mood disorder): 2 people, 5.56%

* Approximation only. Some reports may have incomplete information.

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