Zestoretic and Metoclopramide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zestoretic (hydrochlorothiazide; lisinopril) and Metoclopramide (metoclopramide hydrochloride). Common drug interactions include abdominal mass among females and abdominal pain among males.

The phase IV clinical study analyzes what interactions people have when they take Zestoretic and Metoclopramide. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Zestoretic?

Zestoretic has active ingredients of hydrochlorothiazide; lisinopril. It is often used in high blood pressure. eHealthMe is studying from 4,342 Zestoretic users. Check the latest studies of Zestoretic.

What is Metoclopramide?

Metoclopramide has active ingredients of metoclopramide hydrochloride. It is often used in nausea. eHealthMe is studying from 81,263 Metoclopramide users. Check the latest studies of Metoclopramide.

On Jul, 24, 2026

12 people who take Zestoretic and Metoclopramide together, and have interactions are studied.

Zestoretic and Metoclopramide drug interactions.

What are the common drug interactions of Zestoretic and Metoclopramide, by gender? *:

female:

Abdominal mass (localized enlargement or swelling in the human abdomen)
Abnormal behaviour
Abscess (pus)
Actinomycosis (infection that causes sores, or abscesses)
Acute myocardial infarction (acute heart attack)
Alopecia (absence of hair from areas of the body)
Amyloidosis (a tumour within which amyloid is produced)
Anaemia (lack of blood)
Anal fissure
Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)

male:

Abdominal pain
Arthralgia (joint pain)
Essential hypertension (primary hypertension)
Fatigue (feeling of tiredness)
Gastric ulcer (stomach ulcer)
Heart valve incompetence (heart's valves do not work correctly)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Hiccups (an involuntary spasm of the diaphragm and respiratory organs, with a sudden closure of the glottis and a sound like a cough)
Hypotension (abnormally low blood pressure)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)

What are the common drug interactions of Zestoretic and Metoclopramide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Chronic kidney disease
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Renal tubular necrosis (death of kidney tubules)

40-49:

Chronic kidney disease
Abdominal discomfort
Diabetic ketoacidosis (diabetic ketoacidosis (dka) is high concentrations of ketone bodies)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Mucormycosis (a rare infection caused by organisms that belong to a group of fungi called mucoromycotina)
Renal failure (kidney dysfunction)

50-59:

n/a

60+:

Pain
Abdominal pain
Malaise (a feeling of general discomfort or uneasiness)
Tardive dyskinesia (a disorder that involves involuntary movements)
Alopecia (absence of hair from areas of the body)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anxiety
Balance disorder
Blood glucose increased
Cardiac failure congestive

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 33.33%
Multiple Myeloma (cancer of the plasma cells): 2 people, 16.67%
Impaired Gastric Emptying: 2 people, 16.67%
Diabetes: 2 people, 16.67%
Depression: 2 people, 16.67%
Pain: 1 person, 8.33%
Insomnia (sleeplessness): 1 person, 8.33%
Fungal Infection: 1 person, 8.33%
Fluid Retention (an abnormal accumulation of fluid in the blood): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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