1. Home
  2. Analysis
  3. Zestoretic
  4. Xopenex

Zestoretic and Xopenex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zestoretic (hydrochlorothiazide; lisinopril) and Xopenex (levalbuterol hydrochloride). Common drug interactions include influenza among females.

The phase IV clinical study analyzes what interactions people have when they take Zestoretic and Xopenex. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Zestoretic?

Zestoretic has active ingredients of hydrochlorothiazide; lisinopril. It is often used in high blood pressure. eHealthMe is studying from 4,342 Zestoretic users. Check the latest studies of Zestoretic.

What is Xopenex?

Xopenex has active ingredients of levalbuterol hydrochloride. It is often used in asthma. eHealthMe is studying from 13,816 Xopenex users. Check the latest studies of Xopenex.

On Jul, 10, 2026

15 people who take Zestoretic and Xopenex together, and have interactions are studied.

Zestoretic and Xopenex drug interactions.

What are the common drug interactions of Zestoretic and Xopenex, by gender? *:

female:

  1. Influenza
  2. Cardiac failure congestive
  3. Blindness
  4. Macular degeneration (painless eye condition that leads to the gradual loss of central vision)
  5. Renal impairment (severely reduced kidney function)
  6. Blood cholesterol increased
  7. Blood urine present
  8. Haemorrhage (bleeding)
  9. Left ventricular dysfunction
  10. Lipids increased (excess lipid in body)

male:

n/a

What are the common drug interactions of Zestoretic and Xopenex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

  1. Influenza
  2. Back pain
  3. Blindness
  4. Macular degeneration (painless eye condition that leads to the gradual loss of central vision)
  5. Renal impairment (severely reduced kidney function)
  6. Ankle fracture
  7. Blood cholesterol increased
  8. Blood urine present
  9. Chronic kidney disease
  10. Dizziness

What are the existing conditions these people have? *

  1. Pain: 9 people, 60.00%
  2. Wheezing (a high-pitched whistling sound made while you breath): 8 people, 53.33%
  3. Cough: 8 people, 53.33%
  4. Intervertebral Disc Protrusion (spinal disc protrusion): 5 people, 33.33%
  5. Sinus Congestion (blockage of sinus): 5 people, 33.33%
  6. Diabetes: 5 people, 33.33%
  7. Paranasal Sinus Hypersecretion: 5 people, 33.33%
  8. Dyspnea (difficult or laboured breathing): 5 people, 33.33%
  9. Hypersensitivity: 5 people, 33.33%
  10. Bronchial Hyperreactivity: 3 people, 20.00%

* Approximation only. Some reports may have incomplete information.

Do you take Zestoretic and Xopenex?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Zestoretic and Xopenex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Zestoretic:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Xopenex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Zestoretic and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Xopenex and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide; lisinopril and levalbuterol hydrochloride (the active ingredients of Zestoretic and Xopenex, respectively), and Zestoretic and Xopenex (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe:

© 2026 eHealthMe.com. All rights reserved. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy.