Zestril and Acular drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zestril (lisinopril) and Acular (ketorolac tromethamine). Common drug interactions include macular oedema among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Zestril and Acular. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Zestril?

Zestril has active ingredients of lisinopril. It is often used in high blood pressure. eHealthMe is studying from 22,273 Zestril users. Check the latest studies of Zestril.

What is Acular?

Acular has active ingredients of ketorolac tromethamine. eHealthMe is studying from 1,125 Acular users. Check the latest studies of Acular.

On Jul, 10, 2026

22 people who take Zestril and Acular together, and have interactions are studied.

What are the common drug interactions of Zestril and Acular, by gender? *:

female:

Macular oedema (fluid and protein deposits collect on or under the macula of the eye (a yellow central area of the retina) and causes it to thicken)
Vomiting
Asthma
Blood glucose increased
Ear pain
Fatigue (feeling of tiredness)
Headache (pain in head)
Hyperphagia (an abnormal appetite for food)
Hypoaesthesia (reduced sense of touch or sensation)
Impaired healing

male:

Chronic kidney disease
Eye pain
Bone loss
Emotional distress
Polyarteritis nodosa (progressive disease of connective tissue)
Tooth loss
Acute respiratory failure
Angina pectoris (chest pain due to ischemia of the heart muscle)
Anxiety disorder
Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)

What are the common drug interactions of Zestril and Acular, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Diabetes mellitus non-insulin-dependent
Nausea (feeling of having an urge to vomit)
Psychotic disorder
Vomiting
Macular oedema (fluid and protein deposits collect on or under the macula of the eye (a yellow central area of the retina) and causes it to thicken)
Acquired cystic kidney disease (acquired tumour in kidney)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Asthma
Bone density decreased

50-59:

Vomiting
Arthropathy
Blood cholesterol increased
Blood glucose increased
Cataract (clouding of the lens inside the eye)
Chronic kidney disease
Glaucoma (increased fluid pressure in the eye with vision loss)
Guillain-barre syndrome (the body's immune system attacks its peripheral nervous system)
Lower limb fracture
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

60+:

Eye pain
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Blood glucose decreased
Blood triglycerides increased
Cardiac disorder
Cardiac failure congestive
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Cataract (clouding of the lens inside the eye)
Catheter sepsis (bacterial infection in blood due to catheter)
Cerebral haemorrhage (bleeding within the brain)

What are the existing conditions these people have? *

Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 2 people, 9.09%
Nausea (feeling of having an urge to vomit): 2 people, 9.09%
Macular Oedema (fluid and protein deposits collect on or under the macula of the eye (a yellow central area of the retina) and causes it to thicken): 2 people, 9.09%
Macular Degeneration (painless eye condition that leads to the gradual loss of central vision): 2 people, 9.09%
Hiv Infection: 2 people, 9.09%
High Blood Cholesterol: 2 people, 9.09%
Hepatitis B: 2 people, 9.09%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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