Zestril and Excedrin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zestril (lisinopril) and Excedrin (acetaminophen; aspirin; caffeine). Common drug interactions include chest discomfort among females and cerebral haemorrhage among males.

The phase IV clinical study analyzes what interactions people have when they take Zestril and Excedrin. It is created by eHealthMe based on reports of 39 people who take the same drugs from the FDA, and is updated regularly.

What is Zestril?

Zestril has active ingredients of lisinopril. It is often used in high blood pressure. eHealthMe is studying from 22,273 Zestril users. Check the latest studies of Zestril.

What is Excedrin?

Excedrin has active ingredients of acetaminophen; aspirin; caffeine. It is often used in headache. eHealthMe is studying from 22,740 Excedrin users. Check the latest studies of Excedrin.

On Jul, 19, 2026

39 people who take Zestril and Excedrin together, and have interactions are studied.

What are the common drug interactions of Zestril and Excedrin, by gender? *:

female:

Chest discomfort
Chest pain
Cholecystitis acute (rapid infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Confusional state
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Cough
Decreased appetite

male:

Cerebral haemorrhage (bleeding within the brain)
Cystitis (inflammation of the wall of the bladder)
Vomiting
Acetabulum fracture (socket of the hip joint- fracture)
Anaemia (lack of blood)
Anxiety
Back pain
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chronic kidney disease
Constipation

What are the common drug interactions of Zestril and Excedrin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Drug ineffective
Haematochezia (passage of stools containing blood)
Pruritus (severe itching of the skin)
Vomiting

20-29:

n/a

30-39:

Abdominal pain lower
Altered state of consciousness (altered state of mind)
Back pain
Bipolar disorder (mood disorder)
Conversion disorder (neurological symptoms, such as numbness, blindness, paralysis, or fits without a definable organic cause)
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Herpes simplex (herpes simplex is a common viral infection)
Injury
Lymphadenopathy (disease or enlargement of lymph nodes)

40-49:

n/a

50-59:

Hot flush (sudden feelings of heat)
Small intestinal obstruction (blockage in small intestine)
Thyroid gland cancer
Abdominal pain upper
Anxiety
Cardiac arrest
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chronic kidney disease
Constipation
Diarrhoea

60+:

Constipation
Decreased appetite
Acetabulum fracture (socket of the hip joint- fracture)
Activities of daily living impaired
Adrenal adenoma (benign tumour of the glandular type (adenoma) in the adrenal gland)
Adrenal mass
Anaemia (lack of blood)
Anastomotic stenosis
Anastomotic ulcer
Anhedonia (inability to experience pleasure from activities usually found enjoyable)

What are the existing conditions these people have? *

Pain: 8 people, 20.51%
Nausea (feeling of having an urge to vomit): 8 people, 20.51%
Migraine (headache): 6 people, 15.38%
Stress And Anxiety: 6 people, 15.38%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 12.82%
Insomnia (sleeplessness): 4 people, 10.26%
Bipolar Disorder (mood disorder): 4 people, 10.26%
Nausea And Vomiting: 3 people, 7.69%
Indigestion: 3 people, 7.69%
Depression: 3 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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