Zestril and Ogen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zestril (lisinopril) and Ogen (estropipate). Common drug interactions include insomnia among females and blood beta-d-glucan increased among males.

The phase IV clinical study analyzes what interactions people have when they take Zestril and Ogen. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Zestril?

Zestril has active ingredients of lisinopril. It is often used in high blood pressure. eHealthMe is studying from 22,273 Zestril users. Check the latest studies of Zestril.

What is Ogen?

Ogen has active ingredients of estropipate. eHealthMe is studying from 2,553 Ogen users. Check the latest studies of Ogen.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 16, 2026

13 people who take Zestril and Ogen together, and have interactions are studied.

What are the common drug interactions of Zestril and Ogen, by gender? *:

female:

Insomnia (sleeplessness)
Joint swelling
Oedema lower limb (fluid collection in tissue of lower leg)
Pain
Peripheral neuropathy (damage to nerves of the peripheral nervous system)
Abdominal discomfort
Alopecia (absence of hair from areas of the body)
Anxiety
Blood albumin decreased
Blood in stool

male:

Blood beta-d-glucan increased
Hypercalcaemia (elevated calcium (ca+) level in the blood)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Nephrogenic anaemia (anaemia due to kidney disease)
Pneumonia
Renal failure (kidney dysfunction)
Renal failure acute (rapid kidney dysfunction)
Renal failure chronic (long lasting kidney dysfunction)

What are the common drug interactions of Zestril and Ogen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Furuncle (infection of the hair follicle)
Joint swelling
Oedema peripheral (superficial swelling)
Pain in extremity
Pain of skin

50-59:

Alopecia (absence of hair from areas of the body)
Anxiety
Bradycardia (abnormally slow heart action)
Breast cancer
Breast cancer in situ
Coma (state of unconsciousness lasting more than six hours)
Dry mouth
Fungus urine test positive
Hoarseness (changing voice)
Hot flushes (sudden feelings of heat)

60+:

Insomnia (sleeplessness)
Pain
Difficulty in walking
Dyspnoea (difficult or laboured respiration)
Eye swelling
Fall
Fatigue (feeling of tiredness)
Gait abnormal
Gastric erosions (gradual destruction of surface layer of the membrane lining the stomach)
Gastritis (inflammation of stomach)

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 15.38%
Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 1 person, 7.69%
Asthma: 1 person, 7.69%
Acute Graft Versus Host Disease (acute complication following an allogeneic tissue/blood transplant): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

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