Zestril and Rocephin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zestril (lisinopril) and Rocephin (ceftriaxone sodium). Common drug interactions include hypokalaemia among females and syncope among males.

The phase IV clinical study analyzes what interactions people have when they take Zestril and Rocephin. It is created by eHealthMe based on reports of 92 people who take the same drugs from the FDA, and is updated regularly.

What is Zestril?

Zestril has active ingredients of lisinopril. It is often used in high blood pressure. eHealthMe is studying from 22,273 Zestril users. Check the latest studies of Zestril.

What is Rocephin?

Rocephin has active ingredients of ceftriaxone sodium. It is often used in infection. eHealthMe is studying from 15,665 Rocephin users. Check the latest studies of Rocephin.

On Jul, 09, 2026

92 people who take Zestril and Rocephin together, and have interactions are studied.

What are the common drug interactions of Zestril and Rocephin, by gender? *:

female:

Hypokalaemia (low potassium)
Renal failure acute (rapid kidney dysfunction)
Anaemia (lack of blood)
Asthenia (weakness)
Diarrhoea
Dysphagia (a condition in which swallowing is difficult or painful)
Hypotension (abnormally low blood pressure)
Injury
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pain

male:

Syncope (loss of consciousness with an inability to maintain postural tone)
Endocarditis (inflammation in heart muscle)
Dyspnoea (difficult or laboured respiration)
Nausea (feeling of having an urge to vomit)
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Depression
Erythema (redness of the skin)
Mitral valve incompetence (inefficient heart valve)
Multiple injuries
Thrombocytopenia (decrease of platelets in blood)

What are the common drug interactions of Zestril and Rocephin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Renal failure acute (rapid kidney dysfunction)
Abdominal distension
Abdominal pain
Anaemia (lack of blood)
Blood calcium decreased
Blood creatine increased
Colitis (inflammation of colon)
Constipation
Dehydration (dryness resulting from the removal of water)
Diarrhoea

20-29:

Acute respiratory failure
Brain abscess
Brain oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain)
Cerebral haemorrhage (bleeding within the brain)
Coagulopathy (blood's ability to clot is impaired)
Gingival bleeding (bleeding gums)
Procedural complication
Pulmonary embolism (blockage of the main artery of the lung)
Pyrexia (fever)
Simple partial seizures (seizures which affect only a small region of the brain)

30-39:

Chronic kidney disease
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)

40-49:

Cardiomyopathy (weakening of the heart muscle)
Abdominal pain lower
Blindness
Blood cholesterol increased
Blood potassium increased
Carotid bruit (sound heard over the carotid artery area during auscultation)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Constipation
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diabetic gastroparesis (paralysis of the muscles of the stomach caused by diabetes)

50-59:

Dysphagia (a condition in which swallowing is difficult or painful)
Hypotension (abnormally low blood pressure)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pain
Renal failure (kidney dysfunction)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Abdominal pain
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Asthenia (weakness)
Back pain

60+:

Nausea (feeling of having an urge to vomit)
Syncope (loss of consciousness with an inability to maintain postural tone)
Anxiety
Diarrhoea
Injury
Sepsis (a severe blood infection that can lead to organ failure and death)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Depression
Hypoglycaemia (deficiency of glucose in the bloodstream)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 10 people, 10.87%
Pain: 9 people, 9.78%
High Blood Cholesterol: 9 people, 9.78%
Depression: 8 people, 8.70%
Pneumonia: 5 people, 5.43%

* Approximation only. Some reports may have incomplete information.

Do you take Zestril and Rocephin?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously