Zide and Adderall 5 drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zide (hydrochlorothiazide) and Adderall 5 (amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate). Common drug interactions include pain among females and chest pain among males.

The phase IV clinical study analyzes what interactions people have when they take Zide and Adderall 5. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,246 Zide users. Check the latest studies of Zide.

What is Adderall 5?

Adderall 5 has active ingredients of amphetamine aspartate; amphetamine sulfate; dextroamphetamine saccharate; dextroamphetamine sulfate. It is often used in attention deficit hyperactivity disorder. eHealthMe is studying from 2,997 Adderall 5 users. Check the latest studies of Adderall 5.

On Jul, 06, 2026

24 people who take Zide and Adderall 5 together, and have interactions are studied.

What are the common drug interactions of Zide and Adderall 5, by gender? *:

female:

Pain
Anxiety
Back pain
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Colonic polyp (extra part of colon tissue grow in intestine)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Diverticulum intestinal (a pouch that is attached to the first part of the small intestine)
Dyskinesia (abnormality or impairment of voluntary movement)

male:

Chest pain
Pericarditis (inflammation of the pericardium)

What are the common drug interactions of Zide and Adderall 5, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Injury
Asthenia (weakness)
Bile duct obstruction (blockage in the tubes that carry bile from the liver to the gallbladder)
Blood pressure decreased
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dizziness postural
Fatigue (feeling of tiredness)
Gastrointestinal pain

40-49:

Chest pain
Pericarditis (inflammation of the pericardium)
Abdominal discomfort
Abdominal pain lower
Diarrhoea
Hyperlipidaemia (presence of excess lipids in the blood)
Intestinal obstruction
Pain in extremity
Type 2 diabetes mellitus
Vaginal discharge

50-59:

Tardive dyskinesia (a disorder that involves involuntary movements)
Temporomandibular joint syndrome (pain at the temporomandibular joint due to various causes of increased muscle tension and spasm. it is believed that syndrome is a physical manifestation of psychological stress)
Tenderness (pain or discomfort when an affected area is touched)
Thyroid cancer
Thyroid neoplasm (tumour of thyroid)
Tibia fracture (fracture of lower leg bone)
Tongue disorder (disease of tongue)
Toothache (tooth pain)
Tremor (trembling or shaking movements in one or more parts of your body)
Trigger finger

60+:

Anxiety
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Gait disturbance
Joint swelling
Mean cell haemoglobin increased (more than normal haemoglobin per red blood cell in a sample of blood)
Mean cell volume increased (more than normal average red blood cell volume)
Mean platelet volume decreased (less than normal average size of platelet cells in blood)
Oedema peripheral (superficial swelling)
Pain
Red blood cell abnormality (abnormal red blood cells)

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 7 people, 29.17%
Headache (pain in head): 6 people, 25.00%
Migraine (headache): 4 people, 16.67%
Menopause (end of monthly cycles in women): 4 people, 16.67%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 16.67%
Hyperlipidaemia (presence of excess lipids in the blood): 4 people, 16.67%
Fibromyalgia (a long-term condition which causes pain all over the body): 4 people, 16.67%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 3 people, 12.50%
Pain: 3 people, 12.50%
Hypersensitivity: 3 people, 12.50%

* Approximation only. Some reports may have incomplete information.

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