Zide and Calcium ascorbate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zide (hydrochlorothiazide) and Calcium ascorbate (vitamin c (ascorbic acid)). Common drug interactions include hyponatraemia among females and alcohol abuse among males.

The phase IV clinical study analyzes what interactions people have when they take Zide and Calcium ascorbate. It is created by eHealthMe based on reports of 62 people who take the same drugs from the FDA, and is updated regularly.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,246 Zide users. Check the latest studies of Zide.

What is Calcium ascorbate?

Calcium ascorbate has active ingredients of vitamin c (ascorbic acid). eHealthMe is studying from 1,018 Calcium ascorbate users. Check the latest studies of Calcium ascorbate.

On Aug, 05, 2026

62 people who take Zide and Calcium ascorbate together, and have interactions are studied.

Zide and Calcium ascorbate drug interactions.

What are the common drug interactions of Zide and Calcium Ascorbate, by gender? *:

female:

Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Insomnia (sleeplessness)
Pain
Constipation
Fall
Sedation
Balance disorder
Blood calcium decreased
Creatinine renal clearance decreased
Depressed level of consciousness

male:

Alcohol abuse
Alcoholism (problems with alcohol)
Drug hypersensitivity
Fibromyalgia (a long-term condition which causes pain all over the body)
Gastric disorder (disease of stomach)
Hospitalisation
Nausea (feeling of having an urge to vomit)
Nervousness
Neutropenia (an abnormally low number of neutrophils)
Weight decreased

What are the common drug interactions of Zide and Calcium Ascorbate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Drug hypersensitivity
Fibromyalgia (a long-term condition which causes pain all over the body)
Gastric disorder (disease of stomach)
Hospitalisation
Weight decreased
Weight increased

40-49:

n/a

50-59:

Glucose tolerance impaired (blood glucose is raised beyond normal levels, but not high enough to warrant a diabetes diagnosis)
Renal disorder (kidney disease)
Flushing (the warm, red condition of human skin)
Nonspecific reaction (unspecified reaction)

60+:

Pain
Constipation
Sedation
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Dyspnoea (difficult or laboured respiration)
Drug abuse
Overdose
Nausea (feeling of having an urge to vomit)
Creatinine renal clearance increased
Abdominal pain

What are the existing conditions these people have? *

Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 24 people, 38.71%
Thyroid Diseases: 24 people, 38.71%
Urinary Tract Infection: 23 people, 37.10%
Gastric Ulcer (stomach ulcer): 23 people, 37.10%
Chest Pain: 23 people, 37.10%
Constipation: 23 people, 37.10%
Coronary Heart Disease (narrowing or blockage of the coronary arteries): 23 people, 37.10%
Dementia (madness): 23 people, 37.10%
Fibromyalgia (a long-term condition which causes pain all over the body): 23 people, 37.10%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 23 people, 37.10%

* Approximation only. Some reports may have incomplete information.

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