Zide and Ciprodex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zide (hydrochlorothiazide) and Ciprodex (ciprofloxacin; dexamethasone). Common drug interactions include renal impairment among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Zide and Ciprodex. It is created by eHealthMe based on reports of 56 people who take the same drugs from the FDA, and is updated regularly.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,246 Zide users. Check the latest studies of Zide.

What is Ciprodex?

Ciprodex has active ingredients of ciprofloxacin; dexamethasone. It is often used in otitis. eHealthMe is studying from 1,887 Ciprodex users. Check the latest studies of Ciprodex.

On Jul, 27, 2026

56 people who take Zide and Ciprodex together, and have interactions are studied.

What are the common drug interactions of Zide and Ciprodex, by gender? *:

female:

Renal impairment (severely reduced kidney function)
Abdominal pain
Abdominal tenderness
Activated partial thromboplastin time prolonged
Activities of daily living impaired
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Aortic valve incompetence
Aortic valve sclerosis (narrowing of the aortic valve)
Arrhythmia (irregular heartbeat)
Asthenia (weakness)

male:

Chronic kidney disease
Fall
Loss of consciousness
Myalgia (muscle pain)
Oedema peripheral (superficial swelling)
Pneumonia
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
Pyrexia (fever)
Renal injury (kidney injury)
Respiratory disorder (respiratory disease)

What are the common drug interactions of Zide and Ciprodex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
Loss of consciousness
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
Pyrexia (fever)
Respiratory disorder (respiratory disease)
Tracheostomy infection (infection of trachea surgical opening)
Pneumonia

30-39:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)

40-49:

Chronic kidney disease
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Nephrogenic anaemia (anaemia due to kidney disease)
Pancreatitis (inflammation of pancreas)
Renal failure (kidney dysfunction)
Death
Narrow anterior chamber angle
Vision blurred

50-59:

Peripheral swelling
Pneumonia
Presyncope
Psychological trauma
Sinusitis (inflammation of sinus)
Skin disorder (skin disease)
Skin infection
Subcutaneous abscess
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Temporomandibular joint syndrome (pain at the temporomandibular joint due to various causes of increased muscle tension and spasm. it is believed that syndrome is a physical manifestation of psychological stress)

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Bruxism (habitual grinding of the teeth, typically during sleep)
Cardiac failure congestive
Dyspnoea (difficult or laboured respiration)
Emotional distress
Eye infection
Flushing (the warm, red condition of human skin)
Hyperhidrosis (abnormally increased sweating)
Infection

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 21 people, 37.50%
Pain: 13 people, 23.21%
High Blood Cholesterol: 12 people, 21.43%
Diabetes: 11 people, 19.64%
Depression: 11 people, 19.64%
Infection: 9 people, 16.07%
Diarrhea: 8 people, 14.29%
Stress And Anxiety: 7 people, 12.50%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 7 people, 12.50%
Multiple Allergies (allergy to multiple agents): 6 people, 10.71%

* Approximation only. Some reports may have incomplete information.

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