Zide and Delestrogen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zide (hydrochlorothiazide) and Delestrogen (estradiol valerate). Common drug interactions include fatigue among females.

The phase IV clinical study analyzes what interactions people have when they take Zide and Delestrogen. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,246 Zide users. Check the latest studies of Zide.

What is Delestrogen?

Delestrogen has active ingredients of estradiol valerate. eHealthMe is studying from 320 Delestrogen users. Check the latest studies of Delestrogen.

On Jul, 15, 2026

11 people who take Zide and Delestrogen together, and have interactions are studied.

What are the common drug interactions of Zide and Delestrogen, by gender? *:

female:

Fatigue (feeling of tiredness)
Renal failure (kidney dysfunction)
Drug ineffective
Hot flush (sudden feelings of heat)
Night sweats (sweating in night)
Visual disturbance
Abdominal distension
Abdominal pain
Abdominal pain upper
Alopecia (absence of hair from areas of the body)

male:

n/a

What are the common drug interactions of Zide and Delestrogen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Cardiovascular disorder (heart diseases)
Decreased activity
Delusion (a false belief or opinion)
Emotional distress
Fatigue (feeling of tiredness)
Obstructive airways disorder (a progressive disease that makes it hard to breathe)
Pain
Quality of life decreased

40-49:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Decreased activity
Emotional distress
Fatigue (feeling of tiredness)
Pain
Quality of life decreased
Renal failure (kidney dysfunction)
Renal transplant

50-59:

Cataract (clouding of the lens inside the eye)
Drug ineffective
Hot flush (sudden feelings of heat)
Night sweats (sweating in night)
Visual disturbance
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chronic kidney disease
Drug effect decreased
Impaired driving ability
Renal disorder (kidney disease)

60+:

Abdominal distension
Abdominal pain
Cough
Depression
Diarrhoea
Dysarthria (speech disorder)
Dyskinesia (abnormality or impairment of voluntary movement)
Dysphagia (a condition in which swallowing is difficult or painful)
Dyspnoea (difficult or laboured respiration)
Dyspnoea exertional (breathlessness or shortness of breath)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 36.36%
Nausea (feeling of having an urge to vomit): 3 people, 27.27%
Hiv Infection: 3 people, 27.27%
Sleep Disorder: 2 people, 18.18%
Hypersensitivity: 2 people, 18.18%
Anal Fistula: 1 person, 9.09%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 1 person, 9.09%
Candidiasis (candidiasis or thrush is a fungal infection): 1 person, 9.09%
Cough: 1 person, 9.09%
Dyspnea (difficult or laboured breathing): 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

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