Zide and Inspra drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zide (hydrochlorothiazide) and Inspra (eplerenone). Common drug interactions include urinary tract infection among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Zide and Inspra. It is created by eHealthMe based on reports of 77 people who take the same drugs from the FDA, and is updated regularly.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,246 Zide users. Check the latest studies of Zide.

What is Inspra?

Inspra has active ingredients of eplerenone. It is often used in high blood pressure. eHealthMe is studying from 3,510 Inspra users. Check the latest studies of Inspra.

On Jul, 13, 2026

77 people who take Zide and Inspra together, and have interactions are studied.

What are the common drug interactions of Zide and Inspra, by gender? *:

female:

Urinary tract infection
Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood glucose increased
Injury
Intracardiac thrombus (presence of a circumscribed mass with heart wall)
Mass
Multi-organ failure (multisystem organ failure)
Myalgia (muscle pain)
Nausea (feeling of having an urge to vomit)

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Cardiac failure congestive
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Cardiogenic shock (inadequate circulation of blood)
Chest pain
Palpitations (feelings or sensations that your heart is pounding or racing)
Pneumonia
Renal failure acute (rapid kidney dysfunction)
Dehydration (dryness resulting from the removal of water)

What are the common drug interactions of Zide and Inspra, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cardiac failure congestive
Cholecystitis (infection of gallbladder)
Influenza like illness
Insomnia (sleeplessness)
Urinary tract infection
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Intracardiac thrombus (presence of a circumscribed mass with heart wall)
Mass
Multi-organ failure (multisystem organ failure)

30-39:

Back pain
Dehydration (dryness resulting from the removal of water)
Drug intolerance (drug sensitivity)
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Loss of consciousness
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Polyuria (production of too much dilute urine)
Thirst
Weight decreased

40-49:

Chest pain
Decreased appetite
Drug ineffective
Epistaxis (bleed from the nose)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Sluggishness (lacking alertness)
Stress

50-59:

Erythema (redness of the skin)
Fibrosis (formation of excess fibrous connective tissue in an organ or tissue)
General physical health deterioration (weak health status)
Joint stiffness
Mobility decreased (ability to move is reduced)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Nervousness
Oedema peripheral (superficial swelling)
Pain
Pain of skin

60+:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Pain
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Cardiogenic shock (inadequate circulation of blood)
Palpitations (feelings or sensations that your heart is pounding or racing)
Renal failure acute (rapid kidney dysfunction)
Weight decreased

What are the existing conditions these people have? *

Type 2 Diabetes: 11 people, 14.29%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 11 people, 14.29%
Diabetes: 7 people, 9.09%
Platelet Count Increased: 6 people, 7.79%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 5 people, 6.49%
Cardiac Failure: 4 people, 5.19%

* Approximation only. Some reports may have incomplete information.

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