Zide and Kionex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zide (hydrochlorothiazide) and Kionex (sodium polystyrene sulfonate). Common drug interactions include renal failure among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Zide and Kionex. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,246 Zide users. Check the latest studies of Zide.

What is Kionex?

Kionex has active ingredients of sodium polystyrene sulfonate. eHealthMe is studying from 478 Kionex users. Check the latest studies of Kionex.

On Jul, 08, 2026

26 people who take Zide and Kionex together, and have interactions are studied.

What are the common drug interactions of Zide and Kionex, by gender? *:

female:

Renal failure (kidney dysfunction)
Hypovolaemia (a decreased volume of circulating blood in the body)
Hyperkalaemia (damage to or disease of the kidney)
Multiple injuries
Renal failure acute (rapid kidney dysfunction)
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Cardiac failure congestive
Chronic kidney disease
Ill-defined disorder
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)

male:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Cystoid macular oedema (fluid accumulation after cataract surgery)
Depression
Hyalosis asteroid (degenerative condition of the eye involving small white opacities in the vitreous humour)
Ischaemic cardiomyopathy (weakness in the muscle of the heart due to inadequate oxygen delivery to the myocardium with coronary artery disease)
Post-traumatic stress disorder
Renal hypertension (high blood pressure caused by the kidneys hormonal response)
Renal tubular necrosis (death of kidney tubules)

What are the common drug interactions of Zide and Kionex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Chronic kidney disease
Glomerulonephritis (a group of conditions that affect parts of the kidneys called glomeruli)
Hyperkalaemia (damage to or disease of the kidney)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Hyperphosphataemia (electrolyte disturbance in which there is an abnormally elevated level of phosphate in the blood)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Renal injury (kidney injury)

50-59:

Renal failure (kidney dysfunction)
Hypovolaemia (a decreased volume of circulating blood in the body)
Multiple injuries
Renal failure acute (rapid kidney dysfunction)
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Cardiac failure congestive
Hyperkalaemia (damage to or disease of the kidney)
Ill-defined disorder
Asthenia (weakness)
Bradycardia (abnormally slow heart action)

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Malaise (a feeling of general discomfort or uneasiness)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Diarrhoea
Ischaemic cardiomyopathy (weakness in the muscle of the heart due to inadequate oxygen delivery to the myocardium with coronary artery disease)
Renal hypertension (high blood pressure caused by the kidneys hormonal response)
Renal tubular necrosis (death of kidney tubules)
Tubulointerstitial nephritis (a form of nephritis affecting the interstitium of the kidneys surrounding the tubules)
Type 1 diabetes mellitus

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 12 people, 46.15%
Hyperkalemia (damage to or disease of the kidney): 9 people, 34.62%
Pain: 7 people, 26.92%
Indigestion: 7 people, 26.92%
Infection: 7 people, 26.92%
Fungal Infection: 7 people, 26.92%
Diabetes: 7 people, 26.92%
Depression: 7 people, 26.92%
Skin Infection: 7 people, 26.92%
Cough: 6 people, 23.08%

* Approximation only. Some reports may have incomplete information.

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