Zide and Odefsey drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zide (hydrochlorothiazide) and Odefsey (emtricitabine; rilpivirine hydrochloride; tenofovir alafenamide fumarate). Common drug interactions include mood swings among females and emotional distress among males.

The phase IV clinical study analyzes what interactions people have when they take Zide and Odefsey. It is created by eHealthMe based on reports of 86 people who take the same drugs from the FDA, and is updated regularly.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,246 Zide users. Check the latest studies of Zide.

What is Odefsey?

Odefsey has active ingredients of emtricitabine; rilpivirine hydrochloride; tenofovir alafenamide fumarate. It is often used in hiv infection. eHealthMe is studying from 4,605 Odefsey users. Check the latest studies of Odefsey.

On Aug, 04, 2026

86 people who take Zide and Odefsey together, and have interactions are studied.

What are the common drug interactions of Zide and Odefsey, by gender? *:

female:

Mood swings (an extreme or rapid change in mood)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Peripheral swelling
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Postural reflex impairment
Restlessness (not able to rest)
Skeletal injury (bone and supporting muscle injury)
Sleep disorder
Spinal fracture (fracture in one of vertebrae)

male:

Emotional distress
Pain
Mobility decreased (ability to move is reduced)
Osteopenia (a condition where bone mineral density is lower than normal)
Renal failure (kidney dysfunction)
Arthralgia (joint pain)
Fatigue (feeling of tiredness)
Hand fracture
Foot fracture
Multiple fractures

What are the common drug interactions of Zide and Odefsey, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Pain
Proteinuria (presence of protein in the urine)
Renal disorder (kidney disease)
Renal impairment (severely reduced kidney function)

20-29:

n/a

30-39:

Anxiety
Emotional distress
Pain
Renal failure (kidney dysfunction)
Chronic kidney disease
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Depression
Fatigue (feeling of tiredness)
Renal impairment (severely reduced kidney function)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)

40-49:

Alopecia (absence of hair from areas of the body)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Blood cholesterol increased
Bone disorder
Bone loss
Cough
Multiple fractures
Muscular weakness (muscle weakness)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)

50-59:

Emotional distress
Pain
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Osteoporosis (bones weak and more likely to break)
Bone density decreased
Chronic kidney disease
Osteopenia (a condition where bone mineral density is lower than normal)
Depression
Foot fracture

60+:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Glomerular filtration rate decreased
Hydronephrosis (water inside the kidney)
Renal cyst (kidney cyst)
Back pain
Blood creatinine increased
Depression
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Renal failure (kidney dysfunction)

What are the existing conditions these people have? *

Pain: 8 people, 9.30%
Hypersensitivity: 6 people, 6.98%
Depression: 5 people, 5.81%

* Approximation only. Some reports may have incomplete information.

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