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Zide and Salonpas drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zide (hydrochlorothiazide) and Salonpas (menthol; methyl salicylate). Common drug interactions include alopecia among females and dizziness among males.

The phase IV clinical study analyzes what interactions people have when they take Zide and Salonpas. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,246 Zide users. Check the latest studies of Zide.

What is Salonpas?

Salonpas has active ingredients of menthol; methyl salicylate. eHealthMe is studying from 630 Salonpas users. Check the latest studies of Salonpas.

On Jul, 31, 2026

21 people who take Zide and Salonpas together, and have interactions are studied.

Zide and Salonpas drug interactions.

What are the common drug interactions of Zide and Salonpas, by gender? *:

female:

  1. Alopecia (absence of hair from areas of the body)
  2. Depression
  3. Hair colour changes
  4. Hair disorder
  5. Anxiety
  6. Emotional distress
  7. Pain
  8. Psychological trauma
  9. Application site burn
  10. Application site erythema (redness of the skin at application site)

male:

  1. Dizziness
  2. Anxiety
  3. Abdominal pain
  4. Abdominal pain upper
  5. Adverse drug reaction
  6. Back pain
  7. Drug ineffective
  8. Headache (pain in head)
  9. Nephrolithiasis (calculi in the kidneys)
  10. Ventricular extrasystoles (premature cardiac contraction)

What are the common drug interactions of Zide and Salonpas, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

  1. Application site burn
  2. Application site erythema (redness of the skin at application site)
  3. Application site scar
  4. Cellulitis (infection under the skin)
  5. Chemical injury
  6. Diabetic ulcer
  7. Drug ineffective
  8. Dry gangrene (diminished blood supply due to vascular problems)
  9. Eschar (dead tissue that falls off (sheds) from healthy skin)
  10. Gangrene (body tissue dies)

50-59:

  1. Alopecia (absence of hair from areas of the body)
  2. Anxiety
  3. Pain
  4. Dizziness
  5. Depression
  6. Hair colour changes
  7. Hair disorder
  8. Application site pain
  9. Dyspnoea (difficult or laboured respiration)
  10. Heart rate increased

60+:

  1. Asthenia (weakness)
  2. Adverse drug reaction
  3. Non-cardiac chest pain
  4. Peripheral swelling
  5. Ventricular extrasystoles (premature cardiac contraction)
  6. Application site rash
  7. Diarrhoea
  8. Dizziness
  9. Drug ineffective
  10. Flatulence (flatus expelled through the anus)

What are the existing conditions these people have? *

  1. Breast Cancer Female: 5 people, 23.81%
  2. Breast Cancer: 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

Do you take Zide and Salonpas?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Zide and Salonpas:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Zide:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Salonpas:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Zide and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Salonpas and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on hydrochlorothiazide and menthol; methyl salicylate (the active ingredients of Zide and Salonpas, respectively), and Zide and Salonpas (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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