Zinacef and Solu-cortef drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zinacef (cefuroxime sodium) and Solu-cortef (hydrocortisone sodium succinate). Common drug interactions include thrombocytopenia among females and emotional distress among males.

The phase IV clinical study analyzes what interactions people have when they take Zinacef and Solu-cortef. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Zinacef?

Zinacef has active ingredients of cefuroxime sodium. eHealthMe is studying from 1,802 Zinacef users. Check the latest studies of Zinacef.

What is Solu-cortef?

Solu-cortef has active ingredients of hydrocortisone sodium succinate. eHealthMe is studying from 7,983 Solu-cortef users. Check the latest studies of Solu-cortef.

On Jul, 17, 2026

25 people who take Zinacef and Solu-cortef together, and have interactions are studied.

Zinacef and Solu-cortef drug interactions.

What are the common drug interactions of Zinacef and Solu-Cortef, by gender? *:

female:

Thrombocytopenia (decrease of platelets in blood)
Aphasia (damage to the parts of the brain that control language)
Death
Dyskinesia (abnormality or impairment of voluntary movement)
Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
Feeling of relaxation
Flushing (the warm, red condition of human skin)
Hypersensitivity
Hypertension (high blood pressure)
Hypotonia (low muscle tone)

male:

Emotional distress
Injury
Renal impairment (severely reduced kidney function)
Stress
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Cardiac arrest
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Fungus serology test positive
Gastritis haemorrhagic (inflammation of stomach with bleeding)
Hyperkalaemia (damage to or disease of the kidney)

What are the common drug interactions of Zinacef and Solu-Cortef, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

C-reactive protein increased
Exanthem (rashes on skin by viral infection)
Infection
Pyrexia (fever)

20-29:

n/a

30-39:

Thrombocytopenia (decrease of platelets in blood)

40-49:

Flushing (the warm, red condition of human skin)
Hypersensitivity
Pruritus (severe itching of the skin)
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)

50-59:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Emotional distress
Fear
Injury
Multi-organ failure (multisystem organ failure)
Pain
Renal failure (kidney dysfunction)
Renal impairment (severely reduced kidney function)
Renal injury (kidney injury)

60+:

Pain
Renal failure acute (rapid kidney dysfunction)
Aphasia (damage to the parts of the brain that control language)
Aspartate aminotransferase increased
Blood bilirubin increased
Blood lactate dehydrogenase increased
Cardiac failure
Death
Dilatation ventricular
Dyskinesia (abnormality or impairment of voluntary movement)

What are the existing conditions these people have? *

High Blood Cholesterol: 7 people, 28.00%
Metabolic Acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body): 6 people, 24.00%
Clostridium Difficile Colitis (inflammation of colon by clostridium difficile bacteria infection): 6 people, 24.00%
Sepsis (a severe blood infection that can lead to organ failure and death): 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

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