Zioptan and Prolia drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zioptan (tafluprost) and Prolia (denosumab). Common drug interactions include dyspnoea among females and dry eye among males.

The phase IV clinical study analyzes what interactions people have when they take Zioptan and Prolia. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Zioptan?

Zioptan has active ingredients of tafluprost. It is often used in glaucoma. eHealthMe is studying from 2,512 Zioptan users. Check the latest studies of Zioptan.

What is Prolia?

Prolia has active ingredients of denosumab. It is often used in osteoporosis. eHealthMe is studying from 151,388 Prolia users. Check the latest studies of Prolia.



On Jul, 30, 2026

17 people who take Zioptan and Prolia together, and have interactions are studied.

Zioptan and Prolia drug interactions.

What are the common drug interactions of Zioptan and Prolia, by gender? *:

female:

  1. Dyspnoea (difficult or laboured respiration)
  2. Emphysema (chronic respiratory disease - over inflation of the air sacs (alveoli) in the lungs)
  3. Feeding disorder (when children refuse to eat certain food groups)
  4. Fungal infection
  5. Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
  6. Insomnia (sleeplessness)
  7. Lung disorder (lung disease)
  8. Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
  9. Neuralgia (pain in one or more nerves)
  10. Ovarian cancer (cancer of ovary)

male:

  1. Dry eye (lack of adequate tears)
  2. Neck pain
  3. Vision blurred

What are the common drug interactions of Zioptan and Prolia, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Pruritus (severe itching of the skin)
  2. Rash
  3. Rash macular (small, flat red spots)
  4. Rhinalgia (pain in the nose)
  5. Skin discolouration (change of skin colour)
  6. Skin disorder (skin disease)
  7. Skin exfoliation (removal of the oldest dead skin cells)
  8. Back pain
  9. Insomnia (sleeplessness)
  10. Malaise (a feeling of general discomfort or uneasiness)

60+:

  1. Adverse event
  2. Agitation (state of anxiety or nervous excitement)
  3. Feeding disorder (when children refuse to eat certain food groups)
  4. Fungal infection
  5. Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
  6. Lung disorder (lung disease)
  7. Malaise (a feeling of general discomfort or uneasiness)
  8. Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
  9. Neck pain
  10. Neuralgia (pain in one or more nerves)

What are the existing conditions these people have? *

  1. Anaemia (lack of blood): 11 people, 64.71%
  2. Nausea And Vomiting: 10 people, 58.82%
  3. Hiatal Hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm): 10 people, 58.82%
  4. Hypovitaminosis (any of several diseases caused by deficiency of one or more vitamins): 10 people, 58.82%
  5. Ill-Defined Disorder: 10 people, 58.82%
  6. Thyroid Diseases: 10 people, 58.82%
  7. Lacrimation Increased: 10 people, 58.82%
  8. Lung Disorder (lung disease): 10 people, 58.82%
  9. Glossitis (infection of tongue with soreness): 10 people, 58.82%
  10. Feeling Of Relaxation: 10 people, 58.82%

* Approximation only. Some reports may have incomplete information.

Do you take Zioptan and Prolia?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Zioptan and Prolia:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Zioptan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Prolia:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Zioptan and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Prolia and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on tafluprost and denosumab (the active ingredients of Zioptan and Prolia, respectively), and Zioptan and Prolia (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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