Zofran and Desogen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zofran (ondansetron hydrochloride) and Desogen (desogestrel; ethinyl estradiol). Common drug interactions include weight decreased among females.

The phase IV clinical study analyzes what interactions people have when they take Zofran and Desogen. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Zofran?

Zofran has active ingredients of ondansetron hydrochloride. It is often used in nausea. eHealthMe is studying from 94,987 Zofran users. Check the latest studies of Zofran.

What is Desogen?

Desogen has active ingredients of desogestrel; ethinyl estradiol. It is often used in birth control. eHealthMe is studying from 664 Desogen users. Check the latest studies of Desogen.

On Aug, 04, 2026

25 people who take Zofran and Desogen together, and have interactions are studied.

What are the common drug interactions of Zofran and Desogen, by gender? *:

female:

Weight decreased
Atrial tachycardia (rhythm disturbance that arises in the atria)
Arthralgia (joint pain)
Blood magnesium decreased
Blood sodium decreased
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Decreased appetite
Dehydration (dryness resulting from the removal of water)
Fall
Febrile neutropenia (fever with reduced white blood cells)

male:

n/a

What are the common drug interactions of Zofran and Desogen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Cerebral thrombosis (blood clot in brain)
Superior sagittal sinus thrombosis (blood clot in the dural venous sinuses, which drain blood from the brain)
Transverse sinus thrombosis (a blood clot in transverse sinus)

20-29:

Sinus congestion (blockage of sinus)
Sinusitis (inflammation of sinus)
Swelling face
Bacterial sepsis
Blood chloride increased
Blood culture positive
Blood lactate dehydrogenase increased
Cholecystitis chronic (long lasting infection of gallbladder)
Cold sweat
Cough

30-39:

Atrial tachycardia (rhythm disturbance that arises in the atria)
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Decreased appetite
Fall
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Insomnia (sleeplessness)
International normalised ratio decreased
Night sweats (sweating in night)
Palpitations (feelings or sensations that your heart is pounding or racing)
Peripheral coldness

40-49:

n/a

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 4 people, 16.00%
Fibromyalgia (a long-term condition which causes pain all over the body): 3 people, 12.00%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 3 people, 12.00%
Asthma: 3 people, 12.00%
Pain: 2 people, 8.00%
Ovarian Disorder (disease of ovary): 2 people, 8.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 8.00%
Migraine (headache): 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

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