Zofran and Evening primrose drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zofran (ondansetron hydrochloride) and Evening primrose (evening primrose oil). Common drug interactions include dysmenorrhoea among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Zofran and Evening primrose. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Zofran?

Zofran has active ingredients of ondansetron hydrochloride. It is often used in nausea. eHealthMe is studying from 94,987 Zofran users. Check the latest studies of Zofran.

What is Evening primrose?

Evening primrose has active ingredients of evening primrose oil. It is often used in breast pain. eHealthMe is studying from 1,794 Evening primrose users. Check the latest studies of Evening primrose.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 22, 2026

25 people who take Zofran and Evening primrose together, and have interactions are studied.

Zofran and Evening primrose drug interactions.

What are the common drug interactions of Zofran and Evening Primrose, by gender? *:

female:

Dysmenorrhoea (painful menstruation)
Lymphocyte count decreased
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Uterine haemorrhage (uterine bleeding)
Diarrhoea
Fibromyalgia (a long-term condition which causes pain all over the body)
Irritable bowel syndrome
Arthralgia (joint pain)
Back pain
Headache (pain in head)

male:

Asthenia (weakness)
Malaise (a feeling of general discomfort or uneasiness)
Pain
Pruritus (severe itching of the skin)
Tooth disorder (tooth disease)

What are the common drug interactions of Zofran and Evening Primrose, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Flushing (the warm, red condition of human skin)
Muscle twitching
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Sinusitis (inflammation of sinus)
Tachyphrenia (abnormally rapid mental activity)

30-39:

n/a

40-49:

Device dislocation
Dysmenorrhoea (painful menstruation)
Fatigue (feeling of tiredness)
Lymphocyte count decreased
Menorrhagia (an abnormally heavy bleeding and prolonged menstrual period at regular intervals)
Migraine (headache)
Uterine haemorrhage (uterine bleeding)
Haemangioma of skin (noncancerous, abnormally dense collections of dilated small blood vessels that may occur in the skin or internal organs)
Malignant melanoma in situ (early stage of cancer in melanocyte)
Oral infection

50-59:

Colitis microscopic (inflammation of colon with diarrhoea and abdominal cramps)

60+:

Diarrhoea
Lobar pneumonia (a form of pneumonia that affects a large and continuous area of the lobe of a lung)
Neutropenia (an abnormally low number of neutrophils)
Plasma cell myeloma (cancer that begins in plasma cells)
Anaphylactic reaction (serious allergic reaction)
Angioedema (rapid swelling of the dermis)
Arthralgia (joint pain)

What are the existing conditions these people have? *

Pain: 7 people, 28.00%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 20.00%
Multiple Myeloma (cancer of the plasma cells): 5 people, 20.00%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 12.00%
Migraine Without Aura (headache without neurological problems): 3 people, 12.00%
Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 3 people, 12.00%
Depression: 3 people, 12.00%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 3 people, 12.00%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 8.00%
Overdose: 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

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