Zofran and Naratriptan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zofran (ondansetron hydrochloride) and Naratriptan (naratriptan). Common drug interactions include drug ineffective among females and anxiety among males.

The phase IV clinical study analyzes what interactions people have when they take Zofran and Naratriptan. It is created by eHealthMe based on reports of 64 people who take the same drugs from the FDA, and is updated regularly.

What is Zofran?

Zofran has active ingredients of ondansetron hydrochloride. It is often used in nausea. eHealthMe is studying from 94,987 Zofran users. Check the latest studies of Zofran.

What is Naratriptan?

Naratriptan has active ingredients of naratriptan. It is often used in migraine. eHealthMe is studying from 1,481 Naratriptan users. Check the latest studies of Naratriptan.

On Jul, 10, 2026

64 people who take Zofran and Naratriptan together, and have interactions are studied.

Zofran and Naratriptan drug interactions.

What are the common drug interactions of Zofran and Naratriptan, by gender? *:

female:

Drug ineffective
Dizziness
Hypertension (high blood pressure)
Headache (pain in head)
Urinary tract infection
Abdominal pain
Anxiety
Back pain
Chest pain
Fatigue (feeling of tiredness)

male:

Anxiety
Bone density decreased
Thoracic vertebral fracture
Chronic kidney disease
Fanconi syndrome acquired (self developed genetic disease of kidney damage due to defective transport system)
Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)
Multiple fractures
Spinal compression fracture (fracture due to spinal compression on bone)
Spinal fracture (fracture in one of vertebrae)
Vitamin d deficiency

What are the common drug interactions of Zofran and Naratriptan, by age (0-1 to 60+)? *:

0-1:

Foetal exposure during pregnancy (exposing your unborn child to contraindicated in pregnancy leads birth defect)

2-9:

n/a

10-19:

Arthralgia (joint pain)
Dehydration (dryness resulting from the removal of water)
Dizziness
Hyperaesthesia
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Petit mal epilepsy (absence seizure)
Abdominal pain upper
Anxiety

20-29:

Injection site haemorrhage (bleeding from injection site)
Injection site rash
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Injection site bruising
Injection site mass
Injection site pruritus (severe itching at injection site)

30-39:

Application site burn
Application site swelling
Decreased appetite
Diarrhoea
Dizziness
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dysgeusia (disorder of the sense of taste)
Pulmonary embolism (blockage of the main artery of the lung)

40-49:

Alopecia (absence of hair from areas of the body)
Hair colour changes
Hair disorder
Neoplasm recurrence (reoccurrence of tumour)
Dyspnoea (difficult or laboured respiration)
Fungal infection
Generalised erythema (redness of the skin all over the body)
Headache (pain in head)
Hypotension (abnormally low blood pressure)
Pain

50-59:

Hypertension (high blood pressure)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Sternal fracture
Weight decreased
Drug ineffective
Hypertensive emergency
Anxiety
Bone density decreased
Chronic kidney disease
Depression

60+:

Abdominal pain
Back pain
Urinary tract infection
Abdominal distension
Anorectal disorder
Asthenia (weakness)
Asthma
Bile duct stone
Bone marrow oedema (inflammation that causes much than the needed fluid in a bone)
Bone pain

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 10.94%
Stress And Anxiety: 6 people, 9.38%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 6 people, 9.38%
Insomnia (sleeplessness): 6 people, 9.38%
Indigestion: 6 people, 9.38%
Headache (pain in head): 6 people, 9.38%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 7.81%
Immunodeficiency Common Variable: 5 people, 7.81%
Hypersensitivity: 5 people, 7.81%
Fibromyalgia (a long-term condition which causes pain all over the body): 5 people, 7.81%

* Approximation only. Some reports may have incomplete information.

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