Zofran and Novantrone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zofran (ondansetron hydrochloride) and Novantrone (mitoxantrone hydrochloride). Common drug interactions include decubitus ulcer among females and lung infection among males.

The phase IV clinical study analyzes what interactions people have when they take Zofran and Novantrone. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Zofran?

Zofran has active ingredients of ondansetron hydrochloride. It is often used in nausea. eHealthMe is studying from 94,987 Zofran users. Check the latest studies of Zofran.

What is Novantrone?

Novantrone has active ingredients of mitoxantrone hydrochloride. It is often used in multiple sclerosis. eHealthMe is studying from 3,349 Novantrone users. Check the latest studies of Novantrone.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 20, 2026

48 people who take Zofran and Novantrone together, and have interactions are studied.

Zofran and Novantrone drug interactions.

What are the common drug interactions of Zofran and Novantrone, by gender? *:

female:

Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Depression
Hypertension (high blood pressure)
Malaise (a feeling of general discomfort or uneasiness)
Staphylococcal infection (an infection with staphylococcus bacteria)
Vision blurred
Multiple sclerosis relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Partial seizures (seizures which affect only a part of the brain at onset)
Chest pain
Depressed level of consciousness

male:

Lung infection
Rash
Thrombocytopenia (decrease of platelets in blood)
Multi-organ failure (multisystem organ failure)
Death
Confusional state
Decreased appetite
Disease progression
Headache (pain in head)
Pleural effusion (water on the lungs)

What are the common drug interactions of Zofran and Novantrone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Anxiety
Asthenia (weakness)
Cardiac failure congestive
Cardiomyopathy (weakening of the heart muscle)
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Depression
Dyspnoea (difficult or laboured respiration)
Hypertension (high blood pressure)
Malaise (a feeling of general discomfort or uneasiness)
Staphylococcal infection (an infection with staphylococcus bacteria)

50-59:

Transaminases increased
Cardiac failure congestive
Cardiomegaly (increased size of heart than normal)
Cough
Death
Decreased appetite
Disease progression
Dizziness
Dyspnoea (difficult or laboured respiration)
Dyspnoea at rest (difficult or laboured breathing during rest)

60+:

Neutropenia (an abnormally low number of neutrophils)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Dehydration (dryness resulting from the removal of water)
Dyspnoea (difficult or laboured respiration)
Ejection fraction decreased (systolic heart failure)
Acute respiratory failure
Anaemia (lack of blood)
Aspartate aminotransferase increased
Asthenia (weakness)
Atelectasis (partial or complete collapse of the lung)

What are the existing conditions these people have? *

Fatigue (feeling of tiredness): 10 people, 20.83%
Prostate Cancer: 8 people, 16.67%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 8 people, 16.67%
Psychiatric Symptom: 6 people, 12.50%
Depression: 5 people, 10.42%
Pain: 3 people, 6.25%
Malignant Lymphoid Neoplasm (malignant growth or tumour caused by abnormal and uncontrolled cell division in lymph node): 3 people, 6.25%
Lymphoma (cancer that begins in immune system cells): 3 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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