Zofran and Oxervate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zofran (ondansetron hydrochloride) and Oxervate (cenegermin-bkbj). Common drug interactions include eye pain among females and eye pain among males.

The phase IV clinical study analyzes what interactions people have when they take Zofran and Oxervate. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Zofran?

Zofran has active ingredients of ondansetron hydrochloride. It is often used in nausea. eHealthMe is studying from 94,987 Zofran users. Check the latest studies of Zofran.

What is Oxervate?

Oxervate has active ingredients of cenegermin-bkbj. eHealthMe is studying from 7,219 Oxervate users. Check the latest studies of Oxervate.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 25, 2026

19 people who take Zofran and Oxervate together, and have interactions are studied.

What are the common drug interactions of Zofran and Oxervate, by gender? *:

female:

Eye pain
Eye discharge
Eye irritation
Eyelid pain
Disease recurrence
Asthenopia (eyestrain-tiredness of the eyes caused by prolonged close work by a person with an uncorrected vision problem)
Cardiac failure congestive
Dry eye (lack of adequate tears)
Eye infection
Eyelid irritation

male:

Eye pain
Eye swelling
Hospitalisation
Death
Eye irritation
Ocular hyperaemia (an abnormally large amount of blood in eye)
Dysphagia (a condition in which swallowing is difficult or painful)
Eye discharge
Muscle spasms (muscle contraction)
Vertigo

What are the common drug interactions of Zofran and Oxervate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Eye infection
Eye pain
Eyelid pain
Ocular hyperaemia (an abnormally large amount of blood in eye)

50-59:

Eyelid irritation
Eyelid pain
Eye irritation
Eye pain

60+:

Eye pain
Eye irritation
Eye swelling
Death
Ocular hyperaemia (an abnormally large amount of blood in eye)
Asthenopia (eyestrain-tiredness of the eyes caused by prolonged close work by a person with an uncorrected vision problem)
Dry eye (lack of adequate tears)
Eye discharge

What are the existing conditions these people have? *

Neurotrophic Keratopathy (decreased corneal sensitivity and poor corneal healing): 17 people, 89.47%
Ulcerative Keratitis (ulcerative inflammation of the cornea): 4 people, 21.05%
Hypoaesthesia Eye (reduced sense of touch or sensation on eyes): 4 people, 21.05%
Pneumonia Aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree): 1 person, 5.26%
Keratitis (eye's cornea, the front part of the eye, becomes inflamed): 1 person, 5.26%
Herpes Zoster: 1 person, 5.26%
Gastric Ulcer (stomach ulcer): 1 person, 5.26%
Eyelid Twitch (spontaneous and uncontrolled spasms of the muscles): 1 person, 5.26%
Dry Eyes (lack of adequate tears): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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