Zofran and Oxytrol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zofran (ondansetron hydrochloride) and Oxytrol (oxybutyin). Common drug interactions include neutropenia among females and necrotising fasciitis among males.

The phase IV clinical study analyzes what interactions people have when they take Zofran and Oxytrol. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Zofran?

Zofran has active ingredients of ondansetron hydrochloride. It is often used in nausea. eHealthMe is studying from 94,987 Zofran users. Check the latest studies of Zofran.

What is Oxytrol?

Oxytrol has active ingredients of oxybutyin. It is often used in urge incontinence. eHealthMe is studying from 1,285 Oxytrol users. Check the latest studies of Oxytrol.

On Aug, 01, 2026

12 people who take Zofran and Oxytrol together, and have interactions are studied.

What are the common drug interactions of Zofran and Oxytrol, by gender? *:

female:

Neutropenia (an abnormally low number of neutrophils)
Paralysis
Pollakiuria (abnormally frequent passage of relatively small quantities or urine)
Pyrexia (fever)
Blood pressure fluctuation
Cataract (clouding of the lens inside the eye)
Central nervous system lesion (an abnormality in tissue of brain or spinal cord)
Chest discomfort
Diarrhoea
Dizziness

male:

Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Proctalgia (pain in the rectum)

What are the common drug interactions of Zofran and Oxytrol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Blood pressure fluctuation
Chest discomfort
Dizziness
Headache (pain in head)
Heart rate decreased
Palpitations (feelings or sensations that your heart is pounding or racing)
Vision blurred

30-39:

n/a

40-49:

n/a

50-59:

Diarrhoea
Disease progression
Drug ineffective
Injection site bruising
Chills (felling of cold)
Cervical myelopathy (clinical syndrome characterized by clumsiness in hands; gait imbalance; caused by compression of the spinal cord)
Paralysis
Abdominal pain
Cataract (clouding of the lens inside the eye)
Central nervous system lesion (an abnormality in tissue of brain or spinal cord)

60+:

Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Proctalgia (pain in the rectum)
Inappropriate antidiuretic hormone secretion

What are the existing conditions these people have? *

Lung Cancer - Non-Small Cell (lung cancer): 2 people, 16.67%
Squamous Cell Carcinoma Of The Cervix (cervix cancer of a kind of epithelial cell): 1 person, 8.33%
Multiple Myeloma (cancer of the plasma cells): 1 person, 8.33%
Immunodeficiency: 1 person, 8.33%
Depression: 1 person, 8.33%
Dementia (madness): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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