Zofran and Piperacillin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zofran (ondansetron hydrochloride) and Piperacillin (piperacillin sodium). Common drug interactions include pneumonia among females and sepsis among males.

The phase IV clinical study analyzes what interactions people have when they take Zofran and Piperacillin. It is created by eHealthMe based on reports of 95 people who take the same drugs from the FDA, and is updated regularly.

What is Zofran?

Zofran has active ingredients of ondansetron hydrochloride. It is often used in nausea. eHealthMe is studying from 94,987 Zofran users. Check the latest studies of Zofran.

What is Piperacillin?

Piperacillin has active ingredients of piperacillin sodium. eHealthMe is studying from 5,597 Piperacillin users. Check the latest studies of Piperacillin.

On Jul, 11, 2026

95 people who take Zofran and Piperacillin together, and have interactions are studied.

Zofran and Piperacillin drug interactions.

What are the common drug interactions of Zofran and Piperacillin, by gender? *:

female:

Pneumonia
Febrile neutropenia (fever with reduced white blood cells)
Malaise (a feeling of general discomfort or uneasiness)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Sepsis (a severe blood infection that can lead to organ failure and death)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Hypotension (abnormally low blood pressure)
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Renal failure acute (rapid kidney dysfunction)
Syncope (loss of consciousness with an inability to maintain postural tone)

male:

Sepsis (a severe blood infection that can lead to organ failure and death)
Pyrexia (fever)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cellulitis (infection under the skin)
Confusional state
Hypotension (abnormally low blood pressure)
Necrotising fasciitis (an uncommon life-threatening soft-tissue infection)
Perirectal abscess
Pleural effusion (water on the lungs)
Systemic inflammatory response syndrome (an inflammatory state affecting the whole body, frequently a response of the immune system to infection)

What are the common drug interactions of Zofran and Piperacillin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Sepsis (a severe blood infection that can lead to organ failure and death)
Bone marrow failure
Lung infection
Sinus disorder (disease of sinus)
Abdominal wall infection
Acute lymphocytic leukaemia (cancer of the white blood cells)
Acute sinusitis
Adhesion
Anaemia (lack of blood)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)

10-19:

Abdominal pain
Diarrhoea

20-29:

Cough
Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Pyrexia (fever)

30-39:

Abscess limb (limb infection)
Abscess oral (abscess in the mouth)
Anal abscess
Aphasia (damage to the parts of the brain that control language)
Cerebellar ataxia (loss of coordination)
Confusion
Convulsions (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled of muscles contract and relax rapidly and repeatedly)
Dermatitis bullous (inflammation of the skin characterized by the presence of bullae which are filled with fluid)
Difficulty in walking
Diplopia (double vision)

40-49:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Aphasia (damage to the parts of the brain that control language)
Blood bilirubin increased
Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Hypoxia (low oxygen in tissues)
Pneumonia influenzal (the flu with pneumonia)
Pyrexia (fever)

50-59:

Anal abscess
Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Cardiomegaly (increased size of heart than normal)
Cardiorenal syndrome (kidney failure and heart failure)
Cellulitis (infection under the skin)
Confusional state
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Epistaxis (bleed from the nose)
Febrile neutropenia (fever with reduced white blood cells)

60+:

Sepsis (a severe blood infection that can lead to organ failure and death)
Pneumonia
Hypotension (abnormally low blood pressure)
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Muscle spasms (muscle contraction)
Renal failure acute (rapid kidney dysfunction)
Scrotal abscess (pus in scrotum)
Dizziness
Dyspnoea (difficult or laboured respiration)
Anaemia (lack of blood)

What are the existing conditions these people have? *

High Blood Pressure: 16 people, 16.84%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 13 people, 13.68%
Multiple Myeloma (cancer of the plasma cells): 13 people, 13.68%
Type 2 Diabetes: 12 people, 12.63%
Infection: 12 people, 12.63%
Urinary Tract Infection: 12 people, 12.63%
Weight Decreased: 11 people, 11.58%
Rashes (redness): 11 people, 11.58%
Diabetes: 11 people, 11.58%
Pain: 11 people, 11.58%

* Approximation only. Some reports may have incomplete information.

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