Zofran and Tagrisso drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zofran (ondansetron hydrochloride) and Tagrisso (osimertinib mesylate). Common drug interactions include pancreatitis among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Zofran and Tagrisso. It is created by eHealthMe based on reports of 91 people who take the same drugs from the FDA, and is updated regularly.

What is Zofran?

Zofran has active ingredients of ondansetron hydrochloride. It is often used in nausea. eHealthMe is studying from 94,987 Zofran users. Check the latest studies of Zofran.

What is Tagrisso?

Tagrisso has active ingredients of osimertinib mesylate. eHealthMe is studying from 19,891 Tagrisso users. Check the latest studies of Tagrisso.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

91 people who take Zofran and Tagrisso together, and have interactions are studied.

What are the common drug interactions of Zofran and Tagrisso, by gender? *:

female:

Pancreatitis (inflammation of pancreas)
Rash pustular (redness with pustules)
Sinusitis (inflammation of sinus)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Blood potassium decreased
Fluid retention (an abnormal accumulation of fluid in the blood)
Affect lability (emotional incontinence)
Arthralgia (joint pain)
Crying
Gait disturbance

male:

Death
Fatigue (feeling of tiredness)
Pulmonary embolism (blockage of the main artery of the lung)
Acute respiratory distress syndrome
Anaemia (lack of blood)
Cough
Dyspnoea (difficult or laboured respiration)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
Lung adenocarcinoma (a form of non-small cell lung cancer)

What are the common drug interactions of Zofran and Tagrisso, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Back pain
Death

40-49:

Pain
Dysphonia (speech disorder attributable to a disorder of phonation)
Hand fracture
Muscle spasms (muscle contraction)
Tooth disorder (tooth disease)
Trichorrhexis (a condition in which the hairs break)
Weight increased
Localised infection (infection at the single location)
Skin exfoliation (removal of the oldest dead skin cells)
Cerebral disorder (brain disease)

50-59:

Skin fissures (a crack in the skin)
Subclavian vein thrombosis (abnormal condition in which a clot develops within the subclavian or axillary vein)
Weight decreased
Death
Diarrhoea
Rash
Anxiety
Dry skin
Fatigue (feeling of tiredness)
Jugular vein thrombosis (clot in jugular vein)

60+:

Death
Asthenia (weakness)
Fatigue (feeling of tiredness)
Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection)
Feeling hot
Heart rate irregular
Infection
Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves)
Nail disorder (disease of nail)
Nightmare (unpleasant dream)

What are the existing conditions these people have? *

Lung Neoplasm Malignant (cancer tumour of lung): 38 people, 41.76%
Lung Carcinoma Cell Type Unspecified Stage 0 (the lung cancer has not spread beyond the inner lining of the lung): 18 people, 19.78%
Lung Cancer - Non-Small Cell (lung cancer): 11 people, 12.09%
Lung Carcinoma Cell Type Unspecified Stage I (the lung cancer is small and hasn't spread to the lymph nodes): 8 people, 8.79%
Diarrhea: 8 people, 8.79%
Non-Small Cell Lung Cancer Metastatic (type of epithelial lung cancer spreads to other parts): 6 people, 6.59%
Neoplasm Malignant (cancer tumour): 6 people, 6.59%
Muscle Spasms (muscle contraction): 6 people, 6.59%
Vestibular Disorder (disorders of the body's balance (vestibular) system in the inner ear): 5 people, 5.49%
Urinary Incontinence (inability to control the flow of urine and involuntary urination): 5 people, 5.49%

* Approximation only. Some reports may have incomplete information.

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