Uceris and Zofran drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Uceris (budesonide) and Zofran (ondansetron hydrochloride). Common drug interactions include back pain among females and purpura among males.

The phase IV clinical study analyzes what interactions people have when they take Uceris and Zofran. It is created by eHealthMe based on reports of 37 people who take the same drugs from the FDA, and is updated regularly.

What is Uceris?

Uceris has active ingredients of budesonide. It is often used in ulcerative colitis. eHealthMe is studying from 1,721 Uceris users. Check the latest studies of Uceris.

What is Zofran?

Zofran has active ingredients of ondansetron hydrochloride. It is often used in nausea. eHealthMe is studying from 94,987 Zofran users. Check the latest studies of Zofran.



On Jul, 11, 2026

37 people who take Uceris and Zofran together, and have interactions are studied.

Uceris and Zofran drug interactions.

What are the common drug interactions of Uceris and Zofran, by gender? *:

female:

  1. Back pain
  2. Blood pressure increased
  3. Burning sensation
  4. Constipation
  5. Crying
  6. Dehydration (dryness resulting from the removal of water)
  7. Depressed mood
  8. Depression
  9. Drug hypersensitivity
  10. Drug ineffective

male:

  1. Purpura (purplish discoloration of the skin)
  2. Rash pruritic (redness with itching)
  3. Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
  4. Feeling hot
  5. Frequent bowel movements
  6. Graft versus host disease in skin (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the skin)
  7. Haematochezia (passage of stools containing blood)
  8. Rash
  9. White blood cell count decreased
  10. Abdominal abscess (collection of pus in abdomen)

What are the common drug interactions of Uceris and Zofran, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

  1. Urticaria (rash of round, red welts on the skin that itch intensely)
  2. Vision blurred
  3. Weight decreased
  4. Abdominal pain
  5. Alopecia (absence of hair from areas of the body)
  6. Back pain
  7. Chest pain
  8. Constipation
  9. Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
  10. Dandruff

20-29:

  1. Alopecia (absence of hair from areas of the body)
  2. Contusion (a type of hematoma of tissue in which capillaries)
  3. Serum sickness (hypersensitivity reaction that results from the injection of heterologous or foreign protein or serum)
  4. Skin lesion
  5. Therapeutic response delayed (late preventive response)
  6. Type iv hypersensitivity reaction (delayed type hypersensitivity as the reaction takes two to three days to develop)
  7. Acne (skin problems that cause pimples)
  8. Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)
  9. Fistula discharge (discharge from abnormal passage of structure/organ)
  10. Rectal abscess (pus in rectum)

30-39:

  1. Fatigue (feeling of tiredness)
  2. Body temperature increased
  3. Cellulitis (infection under the skin)
  4. Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
  5. Feeling hot
  6. Frequent bowel movements
  7. Haematochezia (passage of stools containing blood)
  8. White blood cell count decreased
  9. Acne (skin problems that cause pimples)
  10. Crohn's disease (a condition that causes inflammation of the gastrointestinal tract)

40-49:

  1. Back pain
  2. Chest pain
  3. Chills (felling of cold)
  4. Headache (pain in head)
  5. Injection site discomfort
  6. Injection site pain
  7. Intervertebral disc protrusion (spinal disc protrusion)
  8. Kidney infection
  9. Pneumonia
  10. Pyrexia (fever)

50-59:

  1. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
  2. Thrombosis (formation of a blood clot inside a blood vessel)

60+:

  1. Impaired healing
  2. Purpura (purplish discoloration of the skin)
  3. Type 2 diabetes mellitus
  4. Burning sensation
  5. Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
  6. Graft versus host disease in lung (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the lung)
  7. Herpes zoster
  8. Hypertension (high blood pressure)
  9. Increased tendency to bruise (increased tendency to injure the underlying soft tissue or bone)
  10. Osteoarthritis (a joint disease caused by cartilage loss in a joint)

What are the existing conditions these people have? *

  1. Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 7 people, 18.92%
  2. Pain: 6 people, 16.22%
  3. Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 5 people, 13.51%
  4. Cough: 5 people, 13.51%
  5. Itching: 5 people, 13.51%
  6. Migraine (headache): 4 people, 10.81%
  7. Wheezing (a high-pitched whistling sound made while you breath): 3 people, 8.11%
  8. Stress And Anxiety: 3 people, 8.11%
  9. Depression: 3 people, 8.11%
  10. Abdominal Pain: 3 people, 8.11%

* Approximation only. Some reports may have incomplete information.

Do you take Uceris and Zofran?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Uceris and Zofran:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Uceris:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Zofran:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Uceris and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Zofran and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on budesonide and ondansetron hydrochloride (the active ingredients of Uceris and Zofran, respectively), and Uceris and Zofran (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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