Zoladex and Spiriva drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zoladex (goserelin acetate) and Spiriva (tiotropium bromide monohydrate). Common drug interactions include fatigue among females and prostate cancer recurrent among males.

The phase IV clinical study analyzes what interactions people have when they take Zoladex and Spiriva. It is created by eHealthMe based on reports of 78 people who take the same drugs from the FDA, and is updated regularly.

What is Zoladex?

Zoladex has active ingredients of goserelin acetate. It is often used in prostate cancer. eHealthMe is studying from 13,870 Zoladex users. Check the latest studies of Zoladex.

What is Spiriva?

Spiriva has active ingredients of tiotropium bromide monohydrate. It is often used in chronic obstructive pulmonary disease. eHealthMe is studying from 156,666 Spiriva users. Check the latest studies of Spiriva.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

78 people who take Zoladex and Spiriva together, and have interactions are studied.

What are the common drug interactions of Zoladex and Spiriva, by gender? *:

female:

Fatigue (feeling of tiredness)
Gait disturbance
General physical health deterioration (weak health status)
Malignant neoplasm progression (cancer tumour came back)
Neoplasm progression (growth of tumour)
Respiratory failure (inadequate gas exchange by the respiratory system)
Vitritis (inflammation of the vitreous humour of the eye)
Gynaecomastia (enlargement of the gland tissue of the male breast)
Leukoencephalopathy (disease of the white matter in the brain)
Spinal compression fracture (fracture due to spinal compression on bone)

male:

Prostate cancer recurrent
Anaemia (lack of blood)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Transferrin decreased
Osteitis (a general term for inflammation of bone)
Nausea (feeling of having an urge to vomit)
Platelet count decreased
Death
Somnolence (a state of near-sleep, a strong desire for sleep)
Blood pressure decreased

What are the common drug interactions of Zoladex and Spiriva, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Back pain
Bone pain
Cardiac failure
Fatigue (feeling of tiredness)
Gait disturbance
General physical health deterioration (weak health status)
Malignant neoplasm progression (cancer tumour came back)
Neoplasm progression (growth of tumour)
Respiratory failure (inadequate gas exchange by the respiratory system)

40-49:

n/a

50-59:

Extraskeletal ossification (formation of bone tissue outside of bone tissue)
Gynaecomastia (enlargement of the gland tissue of the male breast)
Hilar lymphadenopathy (disease of the lymph nodes due to infection)
Injury
Lung neoplasm (tumour of lung)
Metastases to bone (cancer spreads to bone)
Metastatic neoplasm (spreadable cancer tumour)
Osteonecrosis of jaw (death of bone of jaw)
Pain
Prostate cancer metastatic

60+:

Prostate cancer recurrent
General physical health deterioration (weak health status)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Transferrin decreased
Osteitis (a general term for inflammation of bone)
Nausea (feeling of having an urge to vomit)
Death
Platelet count decreased
Somnolence (a state of near-sleep, a strong desire for sleep)
Blood pressure decreased

What are the existing conditions these people have? *

High Blood Pressure: 12 people, 15.38%
Prostate Cancer Metastatic: 10 people, 12.82%
Acute Myocardial Infarction (acute heart attack): 7 people, 8.97%
Renal Cell Carcinoma (a kidney cancer): 6 people, 7.69%
Diabetes: 6 people, 7.69%
Weight Loss: 5 people, 6.41%
Primary Myelofibrosis (primary disorder of the bone marrow): 5 people, 6.41%
High Blood Cholesterol: 5 people, 6.41%
Dyspnea (difficult or laboured breathing): 5 people, 6.41%

* Approximation only. Some reports may have incomplete information.

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