Zoledronic and Lamotrigine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zoledronic (zoledronic acid) and Lamotrigine (lamotrigine). Common drug interactions include hyperkalaemia among females and staphylococcal infection among males.

The phase IV clinical study analyzes what interactions people have when they take Zoledronic and Lamotrigine. It is created by eHealthMe based on reports of 29 people who take the same drugs from the FDA, and is updated regularly.

What is Zoledronic?

Zoledronic has active ingredients of zoledronic acid. eHealthMe is studying from 29,812 Zoledronic users. Check the latest studies of Zoledronic.

What is Lamotrigine?

Lamotrigine has active ingredients of lamotrigine. It is often used in bipolar disorder. eHealthMe is studying from 76,638 Lamotrigine users. Check the latest studies of Lamotrigine.



On Jul, 27, 2026

29 people who take Zoledronic and Lamotrigine together, and have interactions are studied.

Zoledronic and Lamotrigine drug interactions.

What are the common drug interactions of Zoledronic and Lamotrigine, by gender? *:

female:

  1. Hyperkalaemia (damage to or disease of the kidney)
  2. Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
  3. Thrombocytopenia (decrease of platelets in blood)
  4. Alcoholic pancreatitis
  5. Blood magnesium decreased
  6. Hip arthroplasty
  7. Malignant hypertension (a hypertensive emergency is a condition in which elevated blood pressure results in target organ damage)
  8. Small intestinal obstruction (blockage in small intestine)
  9. Abdominal pain
  10. Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)

male:

  1. Staphylococcal infection (an infection with staphylococcus bacteria)
  2. Nausea (feeling of having an urge to vomit)
  3. Pyrexia (fever)

What are the common drug interactions of Zoledronic and Lamotrigine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Abdominal pain
  2. Chest pain
  3. Dyspnoea (difficult or laboured respiration)
  4. Osteoporosis (bones weak and more likely to break)

40-49:

  1. Tumour marker increased

50-59:

  1. Arthralgia (joint pain)
  2. Clavicle fracture
  3. Contusion (a type of hematoma of tissue in which capillaries)
  4. Fall
  5. Seizure (abnormal excessive or synchronous neuronal activity in the brain)
  6. Tooth fracture
  7. Alcoholic pancreatitis
  8. Small intestinal obstruction (blockage in small intestine)
  9. Cervical vertebral fracture
  10. Neutropenia (an abnormally low number of neutrophils)

60+:

  1. General physical health deterioration (weak health status)
  2. Hyperkalaemia (damage to or disease of the kidney)
  3. Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
  4. Pyrexia (fever)
  5. Rash
  6. Swelling
  7. Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
  8. Thrombocytopenia (decrease of platelets in blood)
  9. Blood magnesium decreased
  10. Hip arthroplasty

What are the existing conditions these people have? *

  1. Multiple Myeloma (cancer of the plasma cells): 7 people, 24.14%
  2. Osteoporosis (bones weak and more likely to break): 3 people, 10.34%
  3. Wheezing (a high-pitched whistling sound made while you breath): 2 people, 6.90%
  4. Weight Loss: 2 people, 6.90%
  5. Vaginal Infection: 2 people, 6.90%
  6. Systemic Mastocytosis (a condition caused by the accumulation of mast cells in more than one part of the body): 2 people, 6.90%
  7. Stress And Anxiety: 2 people, 6.90%
  8. Rosacea (a skin condition that causes facial redness): 2 people, 6.90%
  9. Respiratory Disorder (respiratory disease): 2 people, 6.90%
  10. Pain In Extremity: 2 people, 6.90%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Zoledronic and Lamotrigine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Zoledronic:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Lamotrigine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Zoledronic and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Lamotrigine and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on zoledronic acid and lamotrigine (the active ingredients of Zoledronic and Lamotrigine, respectively), and Zoledronic and Lamotrigine (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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