Zoledronic and Restasis drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zoledronic (zoledronic acid) and Restasis (cyclosporine). Common drug interactions include chest discomfort among females and nausea among males.

The phase IV clinical study analyzes what interactions people have when they take Zoledronic and Restasis. It is created by eHealthMe based on reports of 53 people who take the same drugs from the FDA, and is updated regularly.

What is Zoledronic?

Zoledronic has active ingredients of zoledronic acid. eHealthMe is studying from 29,812 Zoledronic users. Check the latest studies of Zoledronic.

What is Restasis?

Restasis has active ingredients of cyclosporine. It is often used in dry eyes. eHealthMe is studying from 35,199 Restasis users. Check the latest studies of Restasis.



On Jul, 14, 2026

53 people who take Zoledronic and Restasis together, and have interactions are studied.

Zoledronic and Restasis drug interactions.

What are the common drug interactions of Zoledronic and Restasis, by gender? *:

female:

  1. Chest discomfort
  2. Chronic fatigue syndrome (disorder that causes extreme fatigue)
  3. Cyst (a closed sac)
  4. Decreased activity
  5. Decreased appetite
  6. Disturbance in attention
  7. Fibromyalgia (a long-term condition which causes pain all over the body)
  8. Flatulence (flatus expelled through the anus)
  9. Diarrhoea
  10. Dizziness

male:

  1. Nausea (feeling of having an urge to vomit)
  2. Arthralgia (joint pain)
  3. Vomiting
  4. White blood cell count decreased
  5. Diarrhoea
  6. Ear discomfort
  7. Ear infection
  8. Gait disturbance
  9. Headache (pain in head)
  10. Neuropathy peripheral (surface nerve damage)

What are the common drug interactions of Zoledronic and Restasis, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Pyrexia (fever)
  2. Alopecia (absence of hair from areas of the body)
  3. Diarrhoea
  4. Dry skin
  5. Headache (pain in head)
  6. Hepatic enzyme increased
  7. Hot flush (sudden feelings of heat)
  8. Infusion related reaction
  9. Insomnia (sleeplessness)
  10. Multiple allergies (allergy to multiple agents)

60+:

  1. Pain in extremity
  2. Diarrhoea
  3. Dizziness
  4. Drug ineffective
  5. Dysphonia (speech disorder attributable to a disorder of phonation)
  6. Dyspnoea (difficult or laboured respiration)
  7. Ecchymosis (a discoloration of the skin resulting from bleeding underneath)
  8. Laryngitis (inflammation of the larynx)
  9. Loss of proprioception (loss of senses of body and parts)
  10. Nasal oedema (fluid collection in nose)

What are the existing conditions these people have? *

  1. Multiple Myeloma (cancer of the plasma cells): 16 people, 30.19%
  2. Polycythaemia Vera (blood disorder in which the bone marrow makes too many red blood cells): 9 people, 16.98%
  3. Osteoporosis (bones weak and more likely to break): 9 people, 16.98%
  4. Constipation: 7 people, 13.21%
  5. Essential Thrombocythaemia (chronic blood cancer): 7 people, 13.21%
  6. Pain: 7 people, 13.21%
  7. Insomnia (sleeplessness): 7 people, 13.21%
  8. Asthma: 5 people, 9.43%
  9. Cataplexy (loss of muscle tone accompanied by full conscious awareness): 5 people, 9.43%
  10. Fluid Imbalance (imbalance of fluid in body in intake and fluid lost): 5 people, 9.43%

* Approximation only. Some reports may have incomplete information.

Do you take Zoledronic and Restasis?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Zoledronic and Restasis:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Zoledronic:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Restasis:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Zoledronic and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Restasis and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies


How the study uses the data?

The study uses data from the FDA. It is based on zoledronic acid and cyclosporine (the active ingredients of Zoledronic and Restasis, respectively), and Zoledronic and Restasis (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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