Rebif and Zometa drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Rebif (interferon beta-1a) and Zometa (zoledronic acid). Common drug interactions include infection among females and osteonecrosis of jaw among males.

The phase IV clinical study analyzes what interactions people have when they take Rebif and Zometa. It is created by eHealthMe based on reports of 38 people who take the same drugs from the FDA, and is updated regularly.

What is Rebif?

Rebif has active ingredients of interferon beta-1a. It is often used in multiple sclerosis. eHealthMe is studying from 61,126 Rebif users. Check the latest studies of Rebif.

What is Zometa?

Zometa has active ingredients of zoledronic acid. It is often used in multiple myeloma. eHealthMe is studying from 71,434 Zometa users. Check the latest studies of Zometa.

On Jul, 17, 2026

38 people who take Rebif and Zometa together, and have interactions are studied.

What are the common drug interactions of Rebif and Zometa, by gender? *:

female:

Infection
Metastases to bone (cancer spreads to bone)
Dyspnoea (difficult or laboured respiration)
Asthenia (weakness)
Fall
Injection site erythema (redness at injection site)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Pleural effusion (water on the lungs)
Urinary tract infection
Anaemia (lack of blood)

male:

Osteonecrosis of jaw (death of bone of jaw)
Arthralgia (joint pain)
Back pain
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Fall
Herpes zoster
Neuropathy peripheral (surface nerve damage)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteopenia (a condition where bone mineral density is lower than normal)
Cardiomyopathy (weakening of the heart muscle)

What are the common drug interactions of Rebif and Zometa, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Decreased appetite
Dyspnoea (difficult or laboured respiration)
Pain
Thrombocytopenia (decrease of platelets in blood)
Abdominal discomfort
Anaemia (lack of blood)
Aortic arteriosclerosis (hardening of the aortic arteries)
Aortic valve incompetence
Aphthous stomatitis (mouth ulcer)

40-49:

Anxiety
Osteonecrosis of jaw (death of bone of jaw)
Impatience (restlessness)
Injection site erythema (redness at injection site)
Mood altered (changes in mood)
Type 2 diabetes mellitus
Dyspnoea (difficult or laboured respiration)
Pain
Renal failure acute (rapid kidney dysfunction)
Asthenia (weakness)

50-59:

Oedema (fluid collection in tissue)
Anaemia (lack of blood)
Fatigue (feeling of tiredness)
Fall
Metastases to bone (cancer spreads to bone)
Anxiety
Back pain
Balance disorder
Dizziness
Emotional distress

60+:

Osteonecrosis of jaw (death of bone of jaw)
Infection
Urinary tract infection
Arthralgia (joint pain)
Back pain
General physical health deterioration (weak health status)
Pain
Primary sequestrum (piece of dead bone that has become separated during the process of necrosis from normal/sound bone)
Abdominal pain
Blindness unilateral

What are the existing conditions these people have? *

Breast Cancer: 5 people, 13.16%
Relapsing-Remitting Multiple Sclerosis (reoccurrence of an inflammatory disease in which the insulating covers of nerve cells in the brain and spinal cord are damaged): 4 people, 10.53%
Pain: 4 people, 10.53%
Metastases To Bone (cancer spreads to bone): 4 people, 10.53%
Depression: 4 people, 10.53%
Breast Cancer Metastatic: 3 people, 7.89%
Prostate Cancer Metastatic: 2 people, 5.26%
Nausea (feeling of having an urge to vomit): 2 people, 5.26%
Influenza Like Illness: 2 people, 5.26%

* Approximation only. Some reports may have incomplete information.

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