Zonegran and Azithromycin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zonegran (zonisamide) and Azithromycin (azithromycin). Common drug interactions include neck pain among females and decreased appetite among males.

The phase IV clinical study analyzes what interactions people have when they take Zonegran and Azithromycin. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Zonegran?

Zonegran has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 6,211 Zonegran users. Check the latest studies of Zonegran.

What is Azithromycin?

Azithromycin has active ingredients of azithromycin. It is often used in sinusitis. eHealthMe is studying from 40,716 Azithromycin users. Check the latest studies of Azithromycin.

On Aug, 08, 2026

24 people who take Zonegran and Azithromycin together, and have interactions are studied.

Zonegran and Azithromycin drug interactions.

What are the common drug interactions of Zonegran and Azithromycin, by gender? *:

female:

Neck pain
Pyrexia (fever)
Shoulder pain
Sinus tachycardia (a heart rhythm with elevated rate of impulses originating from the sinoatrial node)
Tardive dyskinesia (a disorder that involves involuntary movements)
Temporomandibular joint syndrome (pain at the temporomandibular joint due to various causes of increased muscle tension and spasm. it is believed that syndrome is a physical manifestation of psychological stress)
Urinary tract infection
Vaginal odour
Viral infection
Visual impairment

male:

Decreased appetite
Dehydration (dryness resulting from the removal of water)
Type 2 diabetes mellitus
Emotional disorder
Extrapyramidal disorder (involuntary muscle spasms in the face and neck)
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
Hyperglycaemia (high blood sugar)
Tremor (trembling or shaking movements in one or more parts of your body)
Constipation
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)

What are the common drug interactions of Zonegran and Azithromycin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Bacterial infection
Viral infection

10-19:

n/a

20-29:

Cholecystitis chronic (long lasting infection of gallbladder)
Cholesterosis (abnormal deposition of cholesterol in tissues)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Diarrhoea
Faeces discoloured
Hypokalaemia (low potassium)
Nausea (feeling of having an urge to vomit)
Pain in extremity
Vomiting
Weight decreased

30-39:

Arthralgia (joint pain)
Drug dependence
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Limb injury
Muscle spasms (muscle contraction)
Swelling
Depression
Diarrhoea
Headache (pain in head)
Hyperhidrosis (abnormally increased sweating)

40-49:

n/a

50-59:

Pain
Alopecia (absence of hair from areas of the body)
Drug ineffective
Fatigue (feeling of tiredness)
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
Hyperglycaemia (high blood sugar)
Neuropathy peripheral (surface nerve damage)
Suicidal ideation
Type 2 diabetes mellitus

60+:

Decreased appetite
Dehydration (dryness resulting from the removal of water)
Renal failure (kidney dysfunction)
Suicidal ideation
Tremor (trembling or shaking movements in one or more parts of your body)
Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)
Calciphylaxis (is a syndrome with vascular calcium accumulation)
Cardiac failure congestive
Cerebral atrophy (decrement in size of brain)
Chronic kidney disease

What are the existing conditions these people have? *

Pain: 7 people, 29.17%
Attention Deficit Hyperactivity Disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness): 6 people, 25.00%
Obsessive-Compulsive Disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;): 4 people, 16.67%
Generalized Anxiety Disorder (excessive, uncontrollable, unexplained and often irrational worry): 4 people, 16.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 16.67%
Bipolar Disorder (mood disorder): 4 people, 16.67%
Stress And Anxiety: 3 people, 12.50%
Tuberculin Test Positive: 2 people, 8.33%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 8.33%
Nausea (feeling of having an urge to vomit): 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Zonegran and Azithromycin?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously