Zonegran and Briviact drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zonegran (zonisamide) and Briviact (brivaracetam). Common drug interactions include white blood cell count decreased among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Zonegran and Briviact. It is created by eHealthMe based on reports of 48 people who take the same drugs from the FDA, and is updated regularly.

What is Zonegran?

Zonegran has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 6,211 Zonegran users. Check the latest studies of Zonegran.

What is Briviact?

Briviact has active ingredients of brivaracetam. It is often used in epilepsy. eHealthMe is studying from 3,433 Briviact users. Check the latest studies of Briviact.

On Jul, 08, 2026

48 people who take Zonegran and Briviact together, and have interactions are studied.

Zonegran and Briviact drug interactions.

What are the common drug interactions of Zonegran and Briviact, by gender? *:

female:

White blood cell count decreased
Withdrawal syndrome (a discontinuation syndrome is a set of symptoms occurred due to discontinuation of substance)
Dizziness
Insomnia (sleeplessness)
Aggression
Depression
Status epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure)
Aphasia (damage to the parts of the brain that control language)
Arthropod sting (arthropod bite)
Concussion (short loss of normal brain function in response to a head injury)

male:

Drug ineffective
Irritability
Facial paralysis (loss of function of face muscle)
Influenza
Visual field defect
Abdominal pain
Adverse drug reaction
Adverse event
Anger
Blood glucose decreased

What are the common drug interactions of Zonegran and Briviact, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Status epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure)
Fatigue (feeling of tiredness)
Hypersomnia (excessive daytime sleepiness (eds))
Abnormal behaviour
Anxiety
Insomnia (sleeplessness)
Mania (a state of abnormally elevated or irritable mood)

20-29:

Depression
Insomnia (sleeplessness)
Abdominal pain
Abnormal behaviour
Adverse drug reaction
Adverse event
Aggression
Anger
Blood glucose decreased
Crying

30-39:

Aggression
Decreased appetite
Depression
Drug ineffective
Dysphagia (a condition in which swallowing is difficult or painful)
Hallucination (an experience involving the perception of something not present)
Hostility
Insomnia (sleeplessness)
Lethargy (tiredness)
Mood altered (changes in mood)

40-49:

Aggression
Anxiety
Contusion (a type of hematoma of tissue in which capillaries)
Drug ineffective
Irritability
Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles)
Panic attack

50-59:

Oral infection
Constipation
Diarrhoea
Dysphonia (speech disorder attributable to a disorder of phonation)
Liver injury
Abnormal behaviour
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Blindness
Cluster headache (one-sided head pain with tearing)
Facial paralysis (loss of function of face muscle)

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)

What are the existing conditions these people have? *

Seizures (abnormal excessive or synchronous neuronal activity in the brain): 14 people, 29.17%
Partial Seizures (seizures which affect only a part of the brain at onset): 7 people, 14.58%
Stress And Anxiety: 5 people, 10.42%
Lennox-Gastaut Syndrome (epilepsy characterized by frequent seizures and different seizure types): 4 people, 8.33%
Migraine (headache): 3 people, 6.25%
High Blood Cholesterol: 3 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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