Zonegran and Codeine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zonegran (zonisamide) and Codeine (codeine sulfate). Common drug interactions include drug hypersensitivity among females.

The phase IV clinical study analyzes what interactions people have when they take Zonegran and Codeine. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.

What is Zonegran?

Zonegran has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 6,211 Zonegran users. Check the latest studies of Zonegran.

What is Codeine?

Codeine has active ingredients of codeine sulfate. It is often used in pain. eHealthMe is studying from 42,342 Codeine users. Check the latest studies of Codeine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 18, 2026

18 people who take Zonegran and Codeine together, and have interactions are studied.

What are the common drug interactions of Zonegran and Codeine, by gender? *:

female:

Drug hypersensitivity
Drug ineffective
Aggression
Anxiety
Chest discomfort
Crying
Dysgeusia (disorder of the sense of taste)
Food craving
Gastric disorder (disease of stomach)
Hunger

male:

n/a

What are the common drug interactions of Zonegran and Codeine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Abdominal discomfort
Abdominal distension
Abdominal pain upper
Aggression
Anxiety
Chest discomfort
Crying
Drug ineffective
Dysgeusia (disorder of the sense of taste)
Fall

50-59:

Drug ineffective
Hyperhidrosis (abnormally increased sweating)
Ill-defined disorder
Intervertebral disc protrusion (spinal disc protrusion)
Malaise (a feeling of general discomfort or uneasiness)
Osteoporosis (bones weak and more likely to break)
Psoas abscess (collection of pus in the iliopsoas muscle compartment)
Pyrexia (fever)
Skeletal injury (bone and supporting muscle injury)
Upper limb fracture

60+:

Drug hypersensitivity

What are the existing conditions these people have? *

Sleep Disorder: 2 people, 11.11%
Quit Smoking: 2 people, 11.11%
Immunodeficiency: 2 people, 11.11%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 2 people, 11.11%
Limb Discomfort (discomfort in leg): 1 person, 5.56%
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 1 person, 5.56%
Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

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