Zonegran and Desyrel drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zonegran (zonisamide) and Desyrel (trazodone hydrochloride). Common drug interactions include tremor among females and actinic keratosis among males.

The phase IV clinical study analyzes what interactions people have when they take Zonegran and Desyrel. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Zonegran?

Zonegran has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 6,211 Zonegran users. Check the latest studies of Zonegran.

What is Desyrel?

Desyrel has active ingredients of trazodone hydrochloride. It is often used in insomnia. eHealthMe is studying from 6,595 Desyrel users. Check the latest studies of Desyrel.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 04, 2026

14 people who take Zonegran and Desyrel together, and have interactions are studied.

What are the common drug interactions of Zonegran and Desyrel, by gender? *:

female:

Tremor (trembling or shaking movements in one or more parts of your body)
Weight increased
Agitation (state of anxiety or nervous excitement)
Bipolar disorder (mood disorder)
Chest pain
Confusional state
Drug ineffective
Hyperglycaemia (high blood sugar)
Nightmare (unpleasant dream)
Rash

male:

Actinic keratosis (skin disease due to sun exposure)
Adenoma benign (non-cancerous tumour -secreting)
Melanocytic naevus (a type of lesion that contains nevus cells (a type of melanocyte))
Neuropathy peripheral (surface nerve damage)
Obsessive-compulsive disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Polyp
Rectal haemorrhage (bleeding from anus)
Telangiectasia (small dilated blood vessels near the surface of the skin)
Anal abscess

What are the common drug interactions of Zonegran and Desyrel, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anaemia (lack of blood)

40-49:

Therapeutic response unexpected

50-59:

Balance disorder
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Chest pain
Confusional state
Drug ineffective
Hunger
Hyperglycaemia (high blood sugar)
Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles)
Nightmare (unpleasant dream)
Rash

60+:

n/a

What are the existing conditions these people have? *

Pain: 6 people, 42.86%
Stress And Anxiety: 6 people, 42.86%
Agitation (state of anxiety or nervous excitement): 4 people, 28.57%
Muscle Spasms (muscle contraction): 4 people, 28.57%
Migraine (headache): 4 people, 28.57%
Migraine Without Aura (headache without neurological problems): 3 people, 21.43%
Chest Pain: 3 people, 21.43%
Diabetes: 3 people, 21.43%
Diabetic Foot: 3 people, 21.43%
Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 3 people, 21.43%

* Approximation only. Some reports may have incomplete information.

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