Zonegran and Premarin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Zonegran (zonisamide) and Premarin (estrogens, conjugated). Common drug interactions include pain among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Zonegran and Premarin. It is created by eHealthMe based on reports of 49 people who take the same drugs from the FDA, and is updated regularly.

What is Zonegran?

Zonegran has active ingredients of zonisamide. It is often used in epilepsy. eHealthMe is studying from 6,211 Zonegran users. Check the latest studies of Zonegran.

What is Premarin?

Premarin has active ingredients of estrogens, conjugated. It is often used in hormone replacement therapy. eHealthMe is studying from 99,630 Premarin users. Check the latest studies of Premarin.

On Jul, 19, 2026

49 people who take Zonegran and Premarin together, and have interactions are studied.

Zonegran and Premarin drug interactions.

What are the common drug interactions of Zonegran and Premarin, by gender? *:

female:

Pain
Drug dependence
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Abdominal distension
Dehydration (dryness resulting from the removal of water)
Oedema peripheral (superficial swelling)
Fatigue (feeling of tiredness)
Carpal tunnel syndrome (nerve compression at wrist results numbness weakness, pain , swelling)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Delusional disorder, unspecified type

male:

Death

What are the common drug interactions of Zonegran and Premarin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Angina pectoris (chest pain due to ischemia of the heart muscle)
Balance disorder
Contusion (a type of hematoma of tissue in which capillaries)
Excoriation (to tear or wear off the skin of)
Fall
Gastric ulcer (stomach ulcer)
Hypercholesterolaemia (high levels of cholesterol in the blood)
Hypoaesthesia (reduced sense of touch or sensation)
Injection site haemorrhage (bleeding from injection site)
Joint dislocation (a joint position is changed from normal position)

40-49:

Areflexia (absence of a reflex)
Asthenia (weakness)
Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)
Cholecystitis (infection of gallbladder)
Cholecystitis chronic (long lasting infection of gallbladder)
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Depression
Drug dependence
Drug ineffective
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)

50-59:

Acne (skin problems that cause pimples)
Diarrhoea
Grand mal convulsion (a type of generalized seizure that affects the entire brain)
Injection site haematoma (localized swelling filled with blood at injection site)
Injection site haemorrhage (bleeding from injection site)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Drug level decreased
Hypoaesthesia (reduced sense of touch or sensation)
Abnormal behaviour
Alopecia (absence of hair from areas of the body)

60+:

Abdominal distension
Abnormal faeces (abnormal stool)
Infusion site urticaria (rash of round, red welts on the skin at infusion site)
Infusion site warmth
Pneumonia
Pain
Asthenia (weakness)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Fatigue (feeling of tiredness)
Headache (pain in head)

What are the existing conditions these people have? *

Pain: 8 people, 16.33%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 6 people, 12.24%
High Blood Cholesterol: 5 people, 10.20%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 4 people, 8.16%
Osteoporosis (bones weak and more likely to break): 4 people, 8.16%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 8.16%
Drowsiness: 4 people, 8.16%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 4 people, 8.16%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 8.16%
Urinary Tract Infection: 3 people, 6.12%

* Approximation only. Some reports may have incomplete information.

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